| 中期因子在胃癌中的表达及其意义 |
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| 引用本文： | 石清涛,宁晓明,冯占军.中期因子在胃癌中的表达及其意义[J].肿瘤防治研究,2008,35(1):30-33. |
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| 作者姓名： | 石清涛 宁晓明 冯占军 |
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| 作者单位： | 150040 哈尔滨医科大学附属第三医院病理 科 |
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| 基金项目： | 黑龙江省卫生厅科学研究基金 |
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| 摘 要： | 目的 探讨中期因子（midkine，MK）蛋白在胃癌组织中的表达及其临床意义。方法 采用免疫组织化学SP法检测88例胃癌及其相应癌旁组织中的MK表达情况，并结合临床病理进行统计学分析。结果 MK在胃癌组织中高表达（表达率为77.3%），且明显高于癌旁组织。MK的表达与肿瘤分化程度、浸润深度及临床分期具有统计学意义上的相关性，与胃癌肿瘤的大小、淋巴结转移无统计学意义上的相关性。结论 ＭK可能与胃癌的发生、发展有关，能反映出胃癌组织的恶性程度及侵袭能力。
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| 关 键 词： | 中期因子 胃癌 免疫组织化学 |
| 文章编号： | 1000-8578（2008）01-0030-04 |
| 收稿时间： | 2007-03-06 |
| 修稿时间： | 2007-07-12 |
Expression of Midkine in Gastric Cancer and Its Clinical Significance |
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| SHI Qing-tao,NING Xiao-ming,FENG Zhan-jun.Expression of Midkine in Gastric Cancer and Its Clinical Significance[J].Cancer Research on Prevention and Treatment,2008,35(1):30-33. |
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| Authors: | SHI Qing-tao NING Xiao-ming FENG Zhan-jun |
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| Institution: | Department of Pathology , The Thi rd A f f i l iated Hos pi tal , Harbin Medical Uni versi t y , Harbin 150040 , China |
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| Abstract: | Objective To study the expression of midkine in gastric cancer and the relationship with biological behaviors.Methods Immunohistochemical SP technique was used to detect the expression of MK in 88 cases of gastric cancer and paratumor tissues around gastric cancers.Results The expression of MK in cancer specimens was significantly higher than that in the relevant panatumor tissues.The correlation was observed between the expression of MK and degree of cellular differentation,invasive extent and clinical stage.Whereas,there was no significant relation observed with gross size and metastasis node.Conclusion MK protein may play a role in tumorgenesis and/or progression in gastric cancer.Moreover,MK protein seems to reflect the progression stage of gastric cancer. |
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| Keywords: | Midkine Gastric cancer Immunohistochemistry |
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