咀嚼时局部脑活动的功能性核磁共振成像

目的：应用功能性核磁共振成像（fMRI）探测人吸嚼时的大脑功能活动。方法：要求人在无任何其它躯体活动条件下咀嚼肌以10s运动20s休息的频率进行。选用8例成人冠状切面和横轴面的头部磁共振片，观察脑功能活动情况。结果：①在咀嚼时脑的广泛区域是激活的；②在相对应的咀嚼活动中有优势半球的激活区；③第I躯体感觉区激活的方式远较第I躯体运动区多样化；④在额叶中4例年轻观察对象出现了广泛的神经元激活区，但在老年人很少出现这样的激活区。结论：咀嚼活动除了它本身的功能运动外，在维持脑的活动方面具有重要的作用。同时也说明fMRI在研究活体人脑功能活动方面是一个相当有效的方法。

Functional magnetic resonance imaging of regional brain activity during masticating

Objective: To observe brain activity during masticating in human.Methods:Mastication was performed for 10 seconds and then followed by 20 seconds of rest without any other physical activity.Neural activity of brain was observed on a series of coronal and horizonal fMRI of 8 adult volunteers.Results: ①Widespread regions of the brain were activated during measticating.②Preferential hemispherical activation were observed.③The activation patterns of primary somesthetic cortex region was more diversified than that of the primary somatomotor cortex.④Neurons in the frontal lobes appeared widely activatied in four young subjects while seldom appeared in the older.Conclusions:Mastication may play an important role in maintaining the brain activities besides its physiological effect.In addition, it also was proved that fMAR is a feasible method in the study of the human in vivo.