巴金森氏病智力损害与年龄、病程、运动障碍的关系

巴金森氏病病人的年龄、起病年龄、病程、运动障碍的严重程度与其智力损害的关系至今仍存有争议。为此用定量的临床评定方法、标准化的韦氏成人智力测验对31名连续收选的特发性巴金森氏病进行了研究。结果发现缓动的严重程度与智力损害明显相关,而震颤严重程度与智力损害呈反相关。病人的年龄、起病年龄、病程及强直的程度与智力损害无明显相关。这些结果提示引起缓动的皮层下脑损害同样可能引起智力损害,而有明显震颤的巴金森氏病可能属于该病的早期或属于智力损害较轻的一种巴金森氏病亚型。

Relationships between Intellectual Deficits and Age, Disease Duration and Motor Symptoms in Parkinson''s Disease

The question of whether the age, age of onset, disease duration and severity of motor symptoms in idiopathic Parkinson's disease(PD)is selated with the degree of intellectual deficits is still controversial. This issue was examined in a study of 31 consecutive patients with PD, utilizing quantitative clinical measures and standardized Wechsler Adult Intelligence Scale revised in China (WAIS-RC). Significant correlations were found between the severity of bradykinesia and the impaired performance on WAIS test However the degree of obvious tremor was inverselg correlated with the intellectual scores. The age, age of onset and severity of rigidity were not significantly correlated to intellectual impairments. These results suggest that the intellectual deficits may result from the same subcortical lesion that cause bradykinesia and that PD with predominant tremor could be an early symptom aor subt ypeof Parkinson's disease with relatively intact intellectual function.