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| 内质网应激与肝脏损伤的治疗 | |
| 引用本文： | 黄 啸,周植星,段为钢,江振洲,孙丽新,张陆勇.内质网应激与肝脏损伤的治疗[J].现代药物与临床,2011,26(3):168-173. |
| 作者姓名： | 黄 啸 周植星 段为钢 江振洲 孙丽新 张陆勇 |
| 作者单位： | 1. 中国药科大学江苏省新药筛选中心,江苏南京,210009 2. 天津药物研究院天津市新药设计与发现重点实验室,天津,300193 3. 云南中医学院中医药分子生物学重点实验室,云南昆明,650500 4. 中国药科大学江苏省新药筛选中心,江苏南京210009;中国药科大学药物质量与安全预警教育部重点实验室,江苏南京210009 5. 中国药科大学江苏省新药筛选中心,江苏南京210009;中国药科大学江苏省药效研究与评价服务中心,江苏南京210009 |
| 基金项目： | “十一五”科技重大专项(2009ZX09302-002);中医药行业科研专项(200707008);中央高校基本科研业务费专项资金(ZJ10115) |
| 摘 要： | 内质网应激是一种细胞自我保护性机制的信号反应通路系统,参与许多疾病的生理病理过程.内质网应激参与多种肝脏损伤的发生与发展,包括免疫性肝损伤、病毒性肝损伤、中毒性肝损伤、脂肪性肝损伤等.以内质网应激为切入点,深入探讨内质网应激的分子机制、作用功能,以及内质网应激与各种肝损伤之间的关系.结合临床药物的作用机制,内质网应激可... |
| 关 键 词： | 内质网应激 肝脏损伤 肝病治疗 新药研发 靶点 |
Endoplasmic reticulum stress involved in the treatments of liver injury |
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| HUANG Xiao,ZHOU Zhi-xing,DUAN Wei-gang,JIANG Zhen-zhou,SUN Li-xin and ZHANG Lu-yong.Endoplasmic reticulum stress involved in the treatments of liver injury[J].Drugs & Clinic,2011,26(3):168-173. | |
| Authors: | HUANG Xiao ZHOU Zhi-xing DUAN Wei-gang JIANG Zhen-zhou SUN Li-xin and ZHANG Lu-yong |
| Institution: | 1.Jiangsu Center for Drug Screening,China Pharmaceutical University,Nanjing 210009,China 2.Tianjin Key Laboratory of Molecular Design and Drug Discovery,Tianjin Institute of Pharmaceutical Research,Tianjin 300193, China 3.Key Laboratory of Molecular Biology for Sinomedicine,Yunnan University of Traditional Chinese Medicine,Kunming,650500, China 4.Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China Pharmaceutical University, Nanjing 210009,China 5.Jiangsu Center for Pharmacodynamic Research and Evaluation,China Pharmaceutical University,Nanjing 210009,China |
| Abstract: | Endoplasmic reticulum stress (ERS) is a self-protecting regulation system, which is involved in various physiologial and pathological conditions. It is reported that ERS contributes to the occurrence and development of liver injury, including immunological liver injury, viral hepatitis, hepatic adipose infiltration, and hepatotoxicity, and so on. This review is about the mechanism of ERS on hepatocytes in the pathogenesis of a variety of liver injuries. Combining with the clinical studies, ERS might be a novel therapeutic target in liver injury-related disease. |
| Keywords: | endoplasmic reticulum stress (ERS) liver injury hepatopathy treatment new drugs development targe |
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