| 5－氟尿嘧啶肝素钠－白蛋白毫微粒的研究 |
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| 引用本文： | 杨唐玉.5－氟尿嘧啶肝素钠－白蛋白毫微粒的研究[J].中国药学杂志,1995,30(12):728-729. |
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| 作者姓名： | 杨唐玉 |
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| 作者单位： | 同济医科大学药学院药物研究室 |
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| 摘 要： | 采用乳液固化法制备了肝素钠－牛血清白蛋白毫微粒，并以口服给药的形式，研究毫微粒的肝靶向性。透射电子显微镜测定毫微粒的平均粒径为１８４±３１ｎｍ（ｎ＝３００）。以５－氟尿嘧啶为模型药物，将５－氟尿嘧啶肝素钠－白蛋白毫微粒在酸性条件下１００℃水解２０ｈ，测得５－氟尿嘧啶的平均包封率为２９．５％。体外试验结果表明，５－氟尿嘧啶毫微粒在３７℃的稀盐酸液中７２ｈ累计释药达７９．４８％。
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| 关 键 词： | 5－FU 肝素钠－白蛋白 毫微粒 包封率的测定 体外释药 |
| 收稿时间： | 1994-12-15; |
Study of 5-FU heparin-albumin nanoparticles |
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| Yang Tangyu.Study of 5-FU heparin-albumin nanoparticles[J].Chinese Pharmaceutical Journal,1995,30(12):728-729. |
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| Authors: | Yang Tangyu |
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| Institution: | College of Pharmacy,Tongji Medical University,Wuhan 430030 |
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| Abstract: | 5-Fluorourail nanoparticle was prepared by emusion method, heparin and albuminbeing chosen as carrier. The particle size distribution was measured and the arithmetic mean diam-eter was 184±31 nm（n=300）. The encapsulation efficiency of the 5-FU nanoparticle was deter-mined with the result of 29.5%within 72 hours up to 79%drug release was observed from hep-arin-albumin nanoparticles. |
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| Keywords: | FU heparin-albumin nanoparticle preparation drug release |
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