帕罗西汀治疗老年原发性失眠症的对照研究

目的探讨帕罗西汀治疗老年原发性失眠症的疗效和副作用。方法采用随机单盲安慰剂对照方法将90例老年原发性失眠症患者随机分为帕罗西汀组(30例)、阿普唑仑组(30例)和安慰剂组(30例),对照治疗12周。采用匹兹堡睡眠质量指数、临床疗效和治疗药物副作用量表评定疗效和副作用。结果帕罗西汀组显效率83%,阿普唑仑组53%。经χ2检验,P<0.01。帕罗西汀组常见副作用有口干、便秘、恶心等,但较阿普唑仑组为轻微。结论帕罗西汀治疗老年原发性失眠症疗效确切,副作用轻微。

Paroxetine and Alprazolam in the treatment of senile primary insomnia: a randomized single blind placebo controlled study

Objective To investigate the clinical effect and side effects of paroxetine in the treatment of senile primary insomnia.Methods The90senile patients were randomly divided into paroxetine group(n=30),alprazolam group(n=30),and placebo group(n=30)for12weeks as a treatment course.Effects were evaluated with Pittsburgh Sleep Quality Index(PSQI)and treatment emergent symptoms scale(TESS),before and after the of treatment .Results The excellent response rate of paroxetine group and alprazolam group were83%and53%respectively(P<0.01).The side effects of paroxetine groups were thirst,constipation,nausea,but those were less than that of alprazolam group.Conclusion Paroxetine is an effective drug for the treatment of senile primary insomnia,and the side effect is less.