乳腺原发性鳞状细胞癌16例临床病理分析

 　目的　探讨乳腺原发性鳞状细胞癌的临床病理特征及免疫表型特点。方法　收集1981年1月至2008年12月乳腺原发性鳞状细胞癌16例，12例免疫组织化学（IHC）检测雌激素受体（ER）、孕激素受体（PR）、C-erbB-2、高分子细胞角蛋白（HCK）、Ki-67，并获得随访，对所有病例的临床病理资料进行回顾性分析。结果　乳腺原发性鳞状细胞癌的发病率低，占该院28年间所有乳腺癌的0.8 %，发病年龄25 ~ 72岁，中位年龄49岁。16例均行手术治疗，7例发生腋窝淋巴结转移，3例死于肿瘤复发和转移，ER一般阴性，大部分表达HCK。结论　原发性乳腺鳞状细胞癌的临床表现与一般乳腺癌相比无特异性，确诊需经组织病理学诊断。预后评价不一，有针对性的规范性治疗有待进一步研究。

Clinicopathologic characteristics of primary squamous cell carcinoma of the breast

Objective To investigate the clinicopathologic and immunohistochemicalcharacteristics of primary squamous cell carcinoma of the breast(PSCCB). Methods Sixteen patients with primary squamous cell carcinoma of the breast were retrospectively reviewed. Twelve cases with a follow-up information were evaluated for ER, PR, C-erbB-2, HCK, Ki-67 expression. Results PSCCB is a very rare neoplasm,constituting 0.8 % of all breast carcinoma over 28 years(1981-2008) in our hospital. The patients age varied from 25 to 72, median age is 49 years old. All patients received operative treatment. Seven patients had metastatic disease in axillary lymph nodes. Three patients died from metastases and tumour recurrence.Tumors were usually ER-negative, but most cases showed high molecular cytokeratin (HCK) expression.Conclusion In terms of the clinical feature, there were no differences between the PSCCB and the other breast cancer. PSCCB could be confirmed by pathology. The prognosis is in controversial. Standard therapy should be studied and recommended in future.