Cancellous bone resorption in the proximal ilium of the ovariectomized rat |
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| Authors: | H Devlin PhD M W J Ferguson D H Carter |
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| Institution: | (1) Department of Restorative Dentistry, University Dental Hospital of Manchester, Higher Cambridge St., M15 6FH Manchester, England;(2) Department of Cell and Structural Biology, University of Manchester, Manchester, England;(3) Department of Oral Medicine, University Dental Hospital of Manchester, Manchester, England |
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| Abstract: | Summary Bone histomorphometry was performed on the proximal ilium of mature Sprague-Dawley rats following ovariectomy, and these rats
were compared with sham-operated controls. Bone volume per unit tissue volume (BV/TV), osteoid surface, and the depth and
extent of eroded cavities were measured in animals killed at intervals after operation. The rate of bone loss and the mean
osteoid surface in the proximal ilium of the ovariectomized rats was significantly greater than that of the control rats over
a 210-day postoperative period. The eroded surface and mean trabecular thickness in the proximal ilium of the ovariectomized
rats were not significantly different from that of the control rats, and therefore failed to explain the difference in the
rate of bone loss. The distribution of the depths of trabecular eroded cavities in the ilium of ovariectomized rats was different
from that in the control rats. The loss of trabecular bone mass in the proximal ilium of ovariectomized, mature rats appeared
due to increased activity of individual osteoclasts, rather than to increased osteoclast numbers and thinning of trabeculae. |
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| Keywords: | Ovariectomy Histomorphometry Bone resorption Rat |
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