彩色双功超声对移植肾急性排异及急性肾小管坏死的实验研究

本研究用山羊建立肾移植模型，分为三组：（1）正常对照组；（2）急性肾小管坏死组（ATN）；（3）急性排异组（AR），每组6只。前两组采用自体肾移植，AR组采用同种异体肾移植。结果表明；①肾移植术后，正常对照组、AR组、ATN组移植肾长度均较术前增加，分别为8．4％、28％、12．5％，以AR纷增大明显（P＜0．05），AR组的厚径、体积、皮质厚径也较正常对照组增大（P＜0．05）；②AR组和ATN级皮质部RI均高于正常对照组（P＜0．01），ATN组RI峰值时间早于AR组；③AR组排异早期，肾皮质动脉峰值流速增快；④彩色多普勒能量图评价肾皮质血流灌注明显优于彩色多普勒血流显像。

Experimental Study on Acute Rejection and Acute TubuLar Necrosis of Renal Transplant by Color Duplex Doppler Sonography

The model of renal transplantation in goat was mads. 18 goats were divided onto three groups: (1) con-trol group; (2) acute tubular necrosis (ATN ) group ; (3 ) acute rejection (AR) group, both group (1) and (2 ) had heterotopic autotransplantation in the neck, group (3) had heterotopic allografting in the same site. The results showed: (1 ) the length of renal transplant increased by 8. 4% (control group), 28 % (AR group), 12. 5 % (ATN group) over baseline. The increase of AR group was significant (P<0.05) including thickness, volume and cortex thickness of the renes as compared with those of control group (P<0.05 ). (2) RI of cortex ateries in AR and ATN group were relatively higher than those of the control group (P<0.01), the RI peak time of AR group was earlier than that of ATN group. (3) Early period after acute rejection, peak systolic velocity obviously increased. (4) Color Doppler energy as a method of evaluating the blood perfusion of renal cortex was superior to color Doppler flow imaging.