| 大蒜素/有机凹凸棒黏土/海藻酸钠/壳聚糖复合微球的制备及其性能 |
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| 引用本文： | 吴洁,杨静静.大蒜素/有机凹凸棒黏土/海藻酸钠/壳聚糖复合微球的制备及其性能[J].中国生化药物杂志,2011,32(6). |
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| 作者姓名： | 吴洁 杨静静 |
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| 作者单位： | 淮阴工学院生化学院,江苏省凹土资源利用重点实验室,江苏淮安223003 |
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| 基金项目： | 江苏省工业支撑计划项目(BE2009098) |
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| 摘 要： | 目的制备大蒜素/有机凹凸棒黏土/海藻酸钠/壳聚糖复合微球(ASCM),并研究其载药性能。方法采用复凝聚法制备了ASCM,以复合微球的载药量和包封率为指标,以大蒜素(DATS)为模型药物,考察了有机凹土(OA)/海藻酸钠(SA)质量比、药物含量、复合温度对微球载药性能的影响,并比较了OA加入前后微球的溶胀性能和缓释性能。结果加入OA后,当复合微球中OA:SA为1:3,OA:DATS为1:1时,其载药量和包封率由原来的12.3%和42.3%分别提高到16.8%和66.5%,而在pH 6.8的磷酸盐缓冲溶液中累积释放率降低。结论复合微球可以作为药物的缓释载体。
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| 关 键 词： | 有机凹凸棒黏土 海藻酸钠 壳聚糖 复合微球 大蒜素 载药性能 |
Preparation and the drug loading properties of allicin/attapulgite/sodium alginate and chitosan composite microspheres |
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| WU Jie,YANG Jing-jing.Preparation and the drug loading properties of allicin/attapulgite/sodium alginate and chitosan composite microspheres[J].Chinese Journal of Biochemical Pharmaceutics,2011,32(6). |
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| Authors: | WU Jie YANG Jing-jing |
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| Institution: | WU Jie,YANG Jing-jing(School of Life Science and Chemical Engineering,Huaiyin Institute of Technology,Key Laboratory for Palygorskite Science and Applied Technology of Jiangsu Province,Huaian 223003,China) |
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| Abstract: | Purpose To prepare allicin/organomodified attapulgite/sodium alginate and chitosan composite microspheres(ASCM) and to study their drug loading properties.Methods ASCM was prepared by complex coacervation method and allicin(DATS) was choosen as model drug in the study.The effect of the weight ratio of organomodified attapulgite(OA) to sodium alginate(SA),the drug content and the composite temperature on the drug loading efficiency(LE) and encapsulation efficiency(EE) of the ASCM were investigated.The swelli... |
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| Keywords: | organomodified attapulgite sodium alginate chitosan composite microspheres allicin drug loading properties |
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