| 双氯芬酸钠壳聚糖明胶复合微球的释药机制研究 |
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| 引用本文： | 孙维形,李旭,于莲,苏瑾.双氯芬酸钠壳聚糖明胶复合微球的释药机制研究[J].中国生化药物杂志,2011,32(6). |
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| 作者姓名： | 孙维形 李旭 于莲 苏瑾 |
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| 作者单位： | 佳木斯大学药学院黑龙江省生物药制剂重点实验室,黑龙江佳木斯,154007 |
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| 基金项目： | 黑龙江卫生厅课题(2010-474) |
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| 摘 要： | 目的制备双氯芬酸钠壳聚糖明胶复合微球(DS-CGMs),探讨其体外释药机制。方法建立DS-CGMs体外释放度的测定方法;研究药物从微球中释放的影响因素;分别考查双氯芬酸钠明胶微球(DS-GMs)、双氯芬酸钠壳聚糖微球(DS-CMs)及DS-CGMs的体外释药情况,并通过数学原理和相关模型探讨其释放行为和机制。结果DS-GMs、DS-CMs以扩散和骨架溶蚀作用释放,而DS-CGMs呈骨架溶蚀作用机制,具有更好的缓释效果。结论获得较为满意的DS-CGMs,其体外释药具有一定的缓释性。
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| 关 键 词： | 双氯芬酸钠 壳聚糖 明胶 微球 体外释放 |
Release mechanism studies on diclofenac chitosan gelatin microspheres |
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| SUN Wei-tong,LI Xu,YU Lian,SU Jin.Release mechanism studies on diclofenac chitosan gelatin microspheres[J].Chinese Journal of Biochemical Pharmaceutics,2011,32(6). |
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| Authors: | SUN Wei-tong LI Xu YU Lian SU Jin |
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| Institution: | SUN Wei-tong,LI Xu,YU Lian,SU Jin(Key Laboratory of Biological Medicine Preparations of Heilongjiang Province,Pharmaceutical School of Jiamusi University,Jiamusi 154007,China) |
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| Abstract: | Purpose To prepare the diclofenac sodium chitosan-gelatin microspheres(DS-CGMs)and to investigate the release mechanism of DS-CGMs.Methods The release in vitro assay method was established.The factors affecting the release properties of DS-CGMs were explored.The release properties of DS-GMs,DS-CMs and DS-CGMs were evaluated,and the release properties and mechanism were investigated in accordance with the mathematics principle and relative model.Results The release properties of DS-GMs and DS-CMs were fit fo... |
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| Keywords: | diclofenac sodium chitosan gelatin microspheres release in vitro |
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