| 谷氨酰胺联合氟比洛芬酯对大鼠局灶性脑缺血再灌注损伤的影响 |
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| 引用本文： | 辛志祥,姜虹,朱也森.谷氨酰胺联合氟比洛芬酯对大鼠局灶性脑缺血再灌注损伤的影响[J].上海医学,2011,34(8):581-585. |
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| 作者姓名： | 辛志祥 姜虹 朱也森 |
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| 作者单位： | 200011,上海交通大学医学院附属第九人民医院麻醉科 |
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| 摘 要： | 目的 探讨谷氨酰胺联合氟比洛芬酯对大鼠局灶性脑缺血再灌注损伤的保护作用及机制.方法 改良线栓法制作大鼠大脑中动脉闭塞(MCAO)2 h/再灌注24 h模型.将60只雄性Sprague-Dawley大鼠随机分为5组,每组12只.假手术组（Sham组）不插入线栓,其余操作与缺血再灌注组相同.缺血再灌注组(IR组)分别于插入...
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| 关 键 词： | 谷氨酰胺 氟比洛芬 脑缺血再灌注损伤 |
Protective effects of glutamine combined with flurbiprofen axetil on focal cerebral ischemia-reperfusion injury in rats |
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| XIN Zhixiang,JIANG Hong,ZHU Yesen.Protective effects of glutamine combined with flurbiprofen axetil on focal cerebral ischemia-reperfusion injury in rats[J].Shanghai Medical Journal,2011,34(8):581-585. |
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| Authors: | XIN Zhixiang JIANG Hong ZHU Yesen |
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| Institution: | XIN Zhixiang,JIANG Hong,ZHU Yesen.Department of Anesthesiology,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China |
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| Abstract: | Objective To investigate the protective effects of glutamine combined with flurbiprofen axetil(FPA) on focal cerebral ischemia-reperfusion injury(CIRI) in rats and the related mechanisms.Methods A modified middle cerebral artery occlusion(MCAO) was used to establish a 2 h/reperfusion 24 h CIRI model in rats.Totally 60 Sprague-Dawley rats were evenly randomized into 5 groups,namely,Sham group(sham operation),IR group(normal saline+local cerebral ischemia reperfusion),Gln group(glutamine 0.75 g/kg + local cer... |
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| Keywords: | Glutamine Flurbiprofen Cerebral ischemia reperfusion injury |
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