Regulation of in vitro and in vivo T cell activation by CD43 |
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Authors: | Thurman EC; Walker J; Jayaraman S; Manjunath N; Ardman B; Green JM |
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Institution: | Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA. |
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Abstract: | Accessory molecule interactions can be critical in determining the outcome
of a T cell's encounter with antigen. Cell adhesion proteins may augment T
cell responses by facilitating TCR engagement of the antigen-MHC complex,
while co-stimulatory molecules may deliver distinct signals that modulate T
cell responsiveness. CD43 (leukosialin, sialophorin) has been suggested to
influence cell activation by steric hindrance based upon the large size and
glycosylation of the protein, as well as the relative abundance of the
protein on the cell surface. In this paper we examine both in vitro and in
vivo T cell-dependent responses in CD43-deficient mice. We demonstrate that
T cells from CD43-deficient mice are hyper-responsive following both in
vivo and in vitro activation, and that this is observed in response to not
only TCR-CD3-mediated stimulation, but also following receptor-independent
activation. This data suggests that mechanisms other than non-specific
steric hindrance are important in the regulation of T cell activation by
CD43.
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