| Exosomes in the Immune Response and Tolerance |
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| 作者姓名： | 修方明 曹雪涛 |
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| 作者单位： | Institute of Immunology，Zhejiang University，Hangzhou 310031，China，Institute of Immunology，Zhejiang University，Hangzhou 310031，China Institute of Immunology，Second Military Medical University，Shanghai 200433，China |
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| 摘 要： | Exosomes are small vesicles with endocytic origin secretedby many live cells. They are flattened or round sphere se-questered by a lipid bi-layer visualized by under electronmicroscopy (EM), with sizes from 30 run to 100 nm. Ex-osomes were first described…
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| 关 键 词： | 免疫反应 外来体 排斥反应 细胞功能 |
Exosomes in the Immune Response and Tolerance |
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| Institute of Immunology,Zhejiang University,Hangzhou ,China.Exosomes in the Immune Response and Tolerance[J].Chinese Journal of Microbiology and Immunology,2004,2(4):231-236. |
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| Authors: | Institute of Immunology Zhejiang University Hangzhou China |
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| Institution: | FM Xiu and XT Cao |
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| Abstract: | Exosomes, secreted by many live cells, are small non-cell vesicles with nanoparticle-grade size. In addition to the original function of discarding the uselessful membrane molecules, exosomes are involved in a range of immunoregulatory functions. Dendritic cell-derived exosomes and tumor-derived exosomes are the best characterized vesicles with potent anti- tumor effect by efficiently inducing immune response. Down-regulation of immune response or induction of immune tolerance is another interesting function of exosomes. Further functional studies of the exosomes will shed light on the application of exosomes. |
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| Keywords: | Exosomes Immunoregulation Non-cell vaccine Apoptosis Tolerance |
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