乳腺导管内增生性病变及浸润性癌中雌激素受体亚型表达的比较性研究

目的探讨雌激素受体亚型（ERα和ERβ）在乳腺导管内增生性病变及浸润性乳腺癌中的表达及其相互关系。 方法采用免疫组织化学法检测正常乳腺组织6例，乳腺导管普通型增生(UDH) 11例, 非典型性导管增生(ADH) 7例,导管原位癌(DCIS)23例(其中Ⅰ级8例,Ⅱ级11例,Ⅲ级4例)及浸润性乳腺癌(IBC)11例中ERα和ERβ的表达。 结果ERα的表达在UDH、ADH及Ⅰ级DCIS中呈逐渐增高趋势，而在Ⅲ级DCIS及IBC中的表达降低，ERα的表达在UDH与 DCIS中差异具有统计学意义（P<0.05）；从正常乳腺组织到UDH、ADH、DCIS至IBC的发展过程中ERβ的表达逐渐降低，ERβ的表达在正常乳腺组织与ADH、DCIS和IBC中以及UDH与DCIS和IBC中的差异具有统计学意义（P<0.05）；ERα和ERβ之间表达没有相关性（P>0.05）。结论从乳腺良性增生性病变到浸润性癌的发展过程中ERα和ERβ的表达各不相同，两者可能通过不同的机制参与癌变过程。

Expression of estrogen receptors α and β in introductal proliferative lesions and invasive carcinoma of the breast:A comparative study

ObjectiveTo explore the expressions of estrogen receptors α and β in introductal proliferative lesions and invasive carcinoma of the breast. MethodsImmunohistochemistry was used to determine the expressions of ER α and β in 11 cases of usual ductal hyperplasia(UDH), 7 atypical ductal hyperplasia(ADH), 23 ductal carcinomas in situ(DICS)（8 DCISⅠ,11 DCISⅡ,4 DCIS Ⅲ) and 11 invasive breast carcinomas（IBC）. ResultsThe expression level of ERα increased in UDH, ADH and low grade DCIS, while it decreased in high grade DCIS and IBC. The expression of ERα was higher in UDH than in DCIS（P<0.05）. The expression of ERβ decreased in the transformation from normal breast tissues to UDH, ADH, DCIS and IBC, and there were significant differences between normal breast tissues and ADH, DCIS, IBC, as well as among UDH and DCIS, IBC（P<0.05）. No correlation was found between the expressions of ER α and ERβ（P>0.05）. ConclusionsThe expressions of ER α and β are different in the transformation from introductal proliferative lesions to breast carcinoma, and they may act by different mechanisms in carcinogenesis.