抑郁症和糖尿病共病患者临床特征的研究

目的探讨伴与不伴Ⅱ型糖尿病的抑郁症患者临床特征的差异。方法伴与不伴Ⅱ型糖尿病的抑郁症患者各30例进行1：1配对分组（A组和B组）,使用汉密尔顿抑郁量表（24项,HAMD）和简易智能精神状态检查量表（MMSE）评定两组患者的临床表现,对两组量表评分进行统计学分析。结果A组较B组在HAMD总分以及绝望感、迟缓等因子分增高均十分显著（P均〈0.01）,且焦虑/躯体化、认识障碍、睡眠障碍等因子分均显著增高（P均〈0.05）。A组较B组在MMSE总分以及定向力、回忆等因子分减少均十分显著（P均〈0.01）,记忆力、语言等因子分均显著减少（P均〈0.05）。两组HAMD评分与MMSE评分均呈非常显著负相关。结论抑郁症和Ⅱ型糖尿病共病时患者抑郁症状和认知功能损害均较仅患抑郁症者更为严重,且抑郁症状越严重认知功能损害越严重。

Comparative study of clinical manifestation between depression and depression with diabetes

Objective To explore the difference of clinical manifestation in depression comorbidity with/without Ⅱ-type diabetes. Methods There were 30 patients with depression comorbidity with/without Ⅱ-type diabetes in the A and B group respectively, who were 1 ; 1 paired-sample. They were appraised by Hamilton Depression Rating Scale （HAMD） and Mini-mental State Examination （MMSE）, the scores were statistically analyzed. Results The total scores of HAMD and the factor-scores of hopelessness and retardation in A group were significantly higher than those in B group（P〈0.01）. The factor-scores of anxiety/somatlzation, cognitive disturbance and sleep disturbance in A group were also significantly higher （P〈0.05）. The total scores of MMSE and the factor-scores of orientation, recall, remembrance and speech in A group were significantly lower than those in B group. The total scores of HAMD and MMSE had negative correlation in both groups. Conclusion The depressive symptom and cognition function might have more severe defect in depression comorbidity with Ⅱ-type diabetes, and the more severe depressive symptom, the more severe cognition function.