食管癌术后早期肠内营养的临床研究

目的 :探讨食管癌术后早期肠内营养的可行性、安全性和临床疗效。　方法 :食管癌病人 4 0例随机分为早期肠内营养组 (EEN)和传统肠内营养组 (TEN) ,每组 2 0例。所有病例在术后第 1、5、9天分别测定血清白蛋白(Alb)、前白蛋白 (PA)、转铁蛋白 (TF)和淋巴细胞计数 (TLC) ,临床观察生命体征、胃肠道功能恢复情况以及各种不良反应。　结果 :所有病人在研究期无死亡 ,无严重并发症 ,无明显肝肾功能改变。EEN组较TEN组PA和TF水平以及外周血TLC都明显升高 (P <0 .0 5 ) ;血清Alb水平未见明显改变 ;肛门排气时间较TEN组早 (P <0 .0 5 )。结论 :食管癌术后早期应用肠内营养支持安全可行 ,既能改善营养状态 ,维护和促进胃肠道功能 ,又能提高机体免疫功能

Clinical studies on early postoperative enteral nutrition in patients with esophageal cancer

Objectives:To investigate the safety,feasibility and clinical effects of early EN(EEN) in postoperative patients with esophageal cancer. Methods:On the first postoperative day,40 patients were randomly divided into EEN group and TEN group(traditional enteral nutrition group), 20 patients per group.A series of parameters including plasma protein and lymphocyte count were tested before and after nutritional therapy.The complications,vital signs and resumption of gastrointestinal functions were carefully observed and recorded simultaneously. Results:Neither mortality nor serious morbidity occurred in all patients during the period of study.The concentrations of serum prealbumin and transferrin were significantly elevated after nutritional support in EEN group.The lymphocyte count was also higher in EEN group.The bowel movement resumed significantly earlier in EEN group than in TEN group. Conclusions:Postoperative EEN for esophageal cancer is safe and feasible,not only improving nutritional status and maintaining gastrointestinal function,but also ameliorating immunological function.