晨尿蛋白/尿肌酐与24h尿蛋白定量相关性分析 |
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引用本文: | 贺艳,何永成,徐艺,李伟,郭健英. 晨尿蛋白/尿肌酐与24h尿蛋白定量相关性分析[J]. 罕少疾病杂志, 2012, 19(1): 11-13,27. DOI: 10.3969/j.issn.1009-3257.2012.01.003 |
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作者姓名: | 贺艳 何永成 徐艺 李伟 郭健英 |
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作者单位: | 深圳市第二人民医院肾内科,广东,深圳,518035 |
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摘 要: | 目的探讨晨尿蛋白/尿肌酐(P/Cr)与24h尿蛋白定量之间的相关性。方法选取261例住院患者,共510份标本,对其晨尿P/Cr与24h尿蛋白定量进行相关性分析。采用ROC曲线分析晨尿P/Cr相对于24h尿蛋白定量3.5、1.0和0.5g的诊断界点。结果住院患者晨尿P/Cr与24h尿蛋白定量呈中度相关。按血清白蛋白<30g/L和≥30g/L分组,进一步分析显示:当血清白蛋白<30g/L时晨尿P/Cr与24h尿蛋白定量呈高度相关;当血清白蛋白≥30g/L时晨尿尿蛋白/尿肌酐比值与24h尿蛋白定量亦呈中度相关。应用ROC曲线分析晨尿P/Cr相对于24h尿蛋白定量3.5、1.0和0.5g的诊断界点分别为2.97、0.93和0.64g/gcr时敏感性和特异性最佳。结论监测尿蛋白排出情况时,患者晨尿P/Cr可以替代24h尿蛋白定量。
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关 键 词: | 尿蛋白/尿肌酐比值 24h尿蛋白定量 |
The Correlation Between First Morning Urine Protein-creatinine Ratio and 24-hour Urine Protein Excretion |
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Affiliation: | HE Yan,HE Yong-cheng,XU Yi,et al.Department of Nephrology,the Second People’s Hospital of Shenzhen City,Shenzhen Guangdong 518035,China |
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Abstract: | Objective To evaluate the correlation between 24 hours total urine protei and urine protein-to-creatinine ratio in first morning urine specimens.Methods 510 aliquot of 24-hour urine collections and first morning urine specimens from 261 inpatients were collected,The correlations between P/Cr in first morning urine specimens and urinary protein excretion in 24-hour collections were analyzed.The cutoff values of P/Cr in first morning urine specimens for screening urinary protein excretion of 3.5g,l.0g and 0.5g in 24-hour collections were determined by receiver operating characteristics(ROC)curve.Results There was a moderate significant correlation between the urine protein excretion in 24-hour collections and the P/Cr in first morning urine specimens.Further analysis showed that the correlation was highly significant for patients with Serum Albumin<30g/L.And for patients with Serum Albumin≥30g/L,the correlation was a moderate significant.By ROC curve analysis,the P/Cr of 2.97g/gcr,0.93g/gcr and 0.64g/gcr in first morning urine specimens represented the most appropriate threshold to detect urine protein excretion of 3.5g,1.0 and 0.5g in 24-hour collections,respectively.Conclusions The P/Cr in first morning urine samples can used as an alternative to urine protein excretion in 24-hour collections to monitor the excretion of urine protein in the patients with renal diseases. |
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Keywords: | Protein-to-creatinine ratio 24-hour urine protein excretion |
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