米索前列醇配伍催产素预防剖宫产术后出血的临床观察

目的观察催产素配伍直肠放置米索前列醇预防剖宫产术后出血的临床效果。方法将住院分娩有手术指征、无米索前列醇使用禁忌证的产妇120例分为A、B 2组,2组均于胎儿娩出后立即宫体肌内注射缩宫素20 U,A组术毕立即直肠放置米索前列醇400μg并10%GS加缩宫素20 U静脉滴注;B组术后仅使用10%GS加缩宫素20 U静脉滴注。观察2组预防剖宫产术后出血的临床效果。结果 A组产后2 h出血量、产后24 h出血量明显少于B组,2组比较差异有统计学意义（P〈0.05）。结论米索前列醇配伍催产素用于预防剖宫产术后出血临床效果显著,值得推广应用。

A clinical observation of Misoprostol and Oxytocin on prevention of postcesarean hemorrhage

Objective To observe clinical preventive effect of oxytocin and rectal placed misoprostol on postcesarean hemorrhage.Methods 120 parturient with operative indication and without misoprostal contraindication were divided into A and B groups.All of two groups were injected 20 U oxytocin into uterus immediately after fetal delivery.Misoprostol 400ug rectal were placed and 10%GS with 20 U oxytocin were used by intravenous drip in group A.only 10% GS with 20U oxytocin by intravenous drip were used in B group.The preventive effect of two groups was compared.Results The blood loss of group A at 2 and 24 hours after delivery was significantly less than that of group B(P<0.05).Conclusion The preventive effect of oxytoin and misoprostol for postcesarean hemorrhage is remarkable and it is worth to application and dissemination in clinic.