肝郁化火证的研究进展

肝郁化火证是中医情志致病理论的重要病机之一,其在临床各科均十分常见,病因多由情志所伤,肝气郁结,致郁而化火.肝郁化火证的病机演变比较复杂,可伤阴,还可犯胃、刑金、扰肾、冲心、甚动风夹痰,形成更复杂的病机.肝郁化火证属于里实热证,治疗时除了清肝泻火,还要疏肝解郁.目前,对于肝郁化火证的基础研究,一般认为,肝郁化火时,机体处于炎症反应状态;神经-体液代谢失调;交感神经机能偏亢;机体代谢旺盛,能量储备减少.肝郁化火证患者的易感因素可能与5-羟色胺转运体基因多态性、色氨酸羟化酶基因多态性关系较密切,心理学也证实了TABP之人肝火证的易感性.本文就目前肝郁化火证的中医病因病机,及其相关的现代本质研究进行总结讨论.

Research progress of liver fire caused by emotional problems

Syndrome of stagnation of liver fire is one of the important emotional pathogenic theories of Traditional Chinese Medicine pathogenesis,which are very common in clinic.It＇s caused emotional problems,liver Qi stagnation,which transforms into fire.Evolution of pathogenesis of liver stagnant fire is very complex,hyperactive Yang injuring essence of Yin,but also attacking the stomach,lung,kidney and heart,even forming phlegm and wind pathogenic factor,leading more complex pathogenesis.Syndrome of stagnation of liver-fire belongs to the syndrome of excessive heat in liver,treatment in addition to clearing liver and purging fire,course the liver and resolve depression.For now,basic research of syndrome of stagnation of liver fire mainly related to inflammation,neurohumoral regulation,gene and the personality,and so on.Generally,the body in the inflammatory state;neuro-humoral disorder,hyperfunction of sympathetic nerve function;massive metabolism,reduced energy reserves.Predisposing factor in patients with syndrome of stagnation of liver fire is related to 5-HTTLPR,TPH gene polymorphism and TABP.This article is about research into pathogenesis of traditional Chinese medicine and modern studies.