Serum collagenase-like peptidase activity in rheumatoid arthritis and systemic lupus erythematosus |
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| Authors: | K Iwase-Okada T Nagatsu K Fujita K Torikai T Hamamoto T Shibata Y Maeno S Sakakibara |
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| Affiliation: | 1. Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, Yokohama 227 Japan;2. Institute for Comprehensive Medical Science, Department of Internal Medicine, School of Medicine, Fujita-Gakuen Health University, Toyoake, Aichi 470-11 Japan;3. Peptide Institute, Protein Research Foundation, Minoh, Osaka, 562 Japan;1. Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, YAW 6044, Boston, MA 02115, USA;2. Department of Radiology, Boston University School of Medicine, 830 Harrison Avenue, 3rd Floor, Boston, MA 02118, USA;3. Department of Radiology, Friedrich-Alexander University Erlangen-Nürnberg (FAU) and University Hospital Erlangen, Maximiliansplatz 391054, Erlangen, Germany;4. Institute of Radiology, University Medical Center Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany;5. Department of Radiology, Stanford university, 1201 Welch Rd, P266Stanford, CA 94305, USA;6. Department of Radiology, VA Boston Healthcare System, 1400 VFW Parkway, 1B105, West Roxbury, MA 02132, USA;1. Department of Surgery, Kaizuka City Hospital, Osaka, Japan;2. Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan;1. Division of MR Research, Department of Radiology, The Johns Hopkins University, Park Building, 600 N Wolfe St, Baltimore, MD 21287, USA;2. Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, Texas, USA;3. Systems and Biomedical Engineering Department, Faculty of Engineering, Cairo University, Giza, Egypt;4. Division of Cardiology, Department of Medicine, The Johns Hopkins University, Baltimore, MD, USA;5. The GW Heart and Vascular Institute, George Washington University School of Medicine and Health Sciences, Washington DC, USA |
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| Abstract: | Collagenase-like(CL) peptidase activity in serum, which was measured using a newly synthesized substrate, (succinyl-Gly-Pro-Leu-Gly-Pro)-4-methylcoumaryl-7-amide, was significantly lower in patients with advanced rheumatoid arthritis or with systemic lupus erythematosus than that in normal controls. Decrease of the serum enzyme activity was more pronounced in systemic lupus erythematosus. No significant change in serum CL-peptidase activity was found in other connective tissue diseases such as mixed connective tissue disease and Sjogren's syndrome. |
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