The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes |
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Authors: | Alvarez-Venegas Raul Sadder Monther Hlavacka Andrej Baluska Frantisek Xia Yuannan Lu Guoqing Firsov Alexey Sarath Gautam Moriyama Hideaki Dubrovsky Joseph G Avramova Zoya |
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Affiliation: | School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0118, USA. |
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Abstract: | The Arabidopsis homolog of trithorax, ATX1, regulates numerous functions in Arabidopsis beyond the homeotic genes. Here, we identified genome-wide targets of ATX1 and showed that ATX1 is a receptor for a lipid messenger, phosphatidylinositol 5-phosphate, PI5P. PI5P negatively affects ATX1 activity, suggesting a regulatory pathway connecting lipid-signaling with nuclear functions. We propose a model to illustrate how plants may respond to stimuli (external or internal) that elevate cellular PI5P levels by altering expression of ATX1-controlled genes. |
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