| 开放血管平滑肌细胞Kir6.1/SUR2B降低去窦弓神经大鼠血压波动性 |
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| 引用本文： | 张伟,赵心彬,杨宏,倪敏. 开放血管平滑肌细胞Kir6.1/SUR2B降低去窦弓神经大鼠血压波动性[J]. 第二军医大学学报, 2012, 33(12): 1315-1318 |
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| 作者姓名： | 张伟 赵心彬 杨宏 倪敏 |
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| 作者单位： | 1. 中国人民解放军总后勤部第二门诊部药房,北京,100071
2. 第二军医大学长征医院药剂科,上海,200003 |
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| 摘 要： | 目的 探讨心血管系统不同分子组成的ATP敏感钾通道(KATP)在降低去窦弓神经(SAD)大鼠血压波动性(BPV)中的作用.方法 建立SAD大鼠模型,利用计算机化清醒自由活动大鼠血流动力学监测技术,观察非选择性KATP开放剂吡那地尔、Kir6.1/Sur2B和Kir6.1/Sur1选择性开放剂二氮嗪对SAD大鼠BPV的影响；并观察用Kir6.1/Sur1选择性阻断剂5-羟基癸酸盐(5-HD)、Kir6.2/Sur2A选择性阻断剂HMR1098阻断KATP后,吡那地尔和二氮嗪对SAD大鼠BPV作用的改变.结果 吡那地尔和二氮嗪能够降低SAD大鼠BPV(P＜0.01),阻断Kir6.1/Sur1、Kir6.2/Sur2A后不改变吡那地尔和二氮嗪对BPV的降低作用.结论 开放血管平滑肌细胞Kir6.1/Sur2B能够降低SAD大鼠的BPV.
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| 关 键 词： | 去窦弓神经 血压波动性 KATP通道 血管平滑肌 |
| 收稿时间： | 2012-10-15 |
| 修稿时间： | 2012-12-04 |
Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats |
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| ZHANG Wei,ZHAO Xin-bin,YANG Hong and NI Min. Opening of Kir6.1/SUR2B on vascular smooth cells decreases blood pressure variability in sinoaortic denervated rats[J]. Former Academic Journal of Second Military Medical University, 2012, 33(12): 1315-1318 |
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| Authors: | ZHANG Wei ZHAO Xin-bin YANG Hong NI Min |
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| Affiliation: | 1.Department of Pharmacy, The Second Out-patient Clinics, General Logistics Department of PLA, Beijing 100071, China2.Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China*Corresponding author. |
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| Abstract: | ObjectiveTo determine the role of different molecular compositions of KATP channels in reducing the blood pressure variability (BPV) in conscious,freely-moving sinoaortic denervated (SAD) rats. MethodsSAD rat model was established. Computerized analytic system of blood pressure was used to observe the effects of unselective KATP openers (pinacidil) or Kir6.1/Sur2B and Kir6.1/Sur1 selective opener (diazoxide) on BPV of SAD rats. We also observed the effects of pinacidil and diazoxide on BPV of SAD rats pre-treated with selective Kir6.1/Sur1 antagonist 5-hydroxydecanoic acid (5-HD) and selective Kir6.2/Sur2A antagonist (HMR1098). ResultsBoth pinacidil and diazoxide significantly decreased BPV in SAD rats (P<0.01), and pre-treatment with 5-HD+HMR1098 did not change the effect of either pinacidil or diazoxide on BPV of SAD rats. ConclusionOpening Kir6.1/SUR2B of vascular smooth cells can decrease the BPV levels in SAD rats. |
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