| 盐酸二甲双胍缓释片的制备及缓释性能研究 |
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| 引用本文： | 陈卫 谢锦桃 张霖泽. 盐酸二甲双胍缓释片的制备及缓释性能研究[J]. 现代食品与药品杂志, 2006, 16(1): 31-33 |
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| 作者姓名： | 陈卫 谢锦桃 张霖泽 |
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| 作者单位： | 深圳市中联制药有限公司 广东深圳518004(陈卫，谢锦桃)，广州市医药工业研究所 广州510240(张霖泽) |
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| 摘 要： | 以盐酸二甲双胍为模型药物,以羟丙甲基纤维素及乙基纤维素为缓释骨架材料,制备相对刚性骨架缓释片。羟丙甲基纤维素、乙基纤维素、乳糖用量是影响缓释效果的主要因素。
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| 关 键 词： | 盐酸二甲双胍 缓释 释放度 生物等效性试验 众氏得 |
| 文章编号： | 1673-4610（2006）01-0031-03 |
| 收稿时间： | 2005-10-13 |
| 修稿时间： | 2005-12-23 |
Prepartion and Release of Metformin Hydrochloride Sustained-release Tablets |
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| CHEN Wei ,XIE Jin-tao ,ZHAN Lin-zhe. Prepartion and Release of Metformin Hydrochloride Sustained-release Tablets[J]. JOurnal of Modern Food and Pharmaceuticals, 2006, 16(1): 31-33 |
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| Authors: | CHEN Wei XIE Jin-tao ZHAN Lin-zhe |
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| Abstract: | Sustained-release Tablets is prepared using metformin hydrochloride as model drug,soluble HPMC and insoluble ethylcellulose as sustained material.The results showed that phamarcokinetic characteristics was very similar between Metformin Hydrochloride Sustained-release Tablets and GLUCOPHAGE XR.Two formulations were bioequivalent. |
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| Keywords: | metformin hydrochloride Sustained-release bioequivalent. |
| 本文献已被 CNKI 维普 等数据库收录！ |
