| A2B型腺苷受体拮抗剂的研究进展 |
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| 引用本文： | 魏静,于文全,高清志.A2B型腺苷受体拮抗剂的研究进展[J].药学学报,2008,43(3):241-246. |
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| 作者姓名： | 魏静 于文全 高清志 |
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| 作者单位： | 1. 天津大学,药物科学与技术学院,天津,300072
2. 美国硅谷生物科技制药公司,3410 Central Expressway,Santa Clara,California 95051 |
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| 摘 要： | A2B腺苷受体参与激活肥大细胞和炎症细胞的活性功能，选择性A2B腺苷受体作为潜在的药物靶点正逐渐成为一个充满希望的研究热点。本文对近年来国内外有关A2B腺苷受体拮抗剂的文献资料进行了分析和归纳。首先介绍了选择性A2B腺苷受体拮抗剂药理学作用和开发意义；然后对选择性A2B腺苷受体拮抗剂的开发现状、构效关系及拮抗剂与受体相互作用情况作了深入讨论；最后，对选择性A2B腺苷受体拮抗剂研发前景进行了展望。
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| 关 键 词： | 腺苷受体 选择性拮抗剂 构效关系 |
| 文章编号： | 0513-4870（2008）03-0241-06 |
| 收稿时间： | 2007-09-05 |
| 修稿时间： | 2007年9月5日 |
Advances in the study of A2B adenosine receptor antagonists |
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| WEI Jing,YU Wen-quan,GAO Qing-zhi.Advances in the study of A2B adenosine receptor antagonists[J].Acta Pharmaceutica Sinica,2008,43(3):241-246. |
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| Authors: | WEI Jing YU Wen-quan GAO Qing-zhi |
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| Institution: | School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. |
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| Abstract: | A2B adenosine receptor is involved in the control of mast cell degranulation, interleukin-8 synthesis and cell growth. A2B adenosine receptor antagonists may serve as novel drugs for asthma, Alzheimer' s disease, cystic fibrosis and type-II diabetes. Therefore, seeking for the highly selective A2B adenosine receptor antagonists has been one of great interest. The molecular basis, structure-activity relationship of selective A2B adenosine receptor antagonists and their interactions with A2B adenosine receptor were reviewed. |
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| Keywords: | adenosine receptor selective antagonist structure-activity relationship |
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