1949-2009年海藻、甘草同方配伍临床应用文献分析

探讨近60年(1949-2009年)的现代文献中海藻、甘草反药同方配伍在临床中的应用特点.利用关联规则对其组方配伍特点进行挖掘,并对剂量、疾病等进行统计分析.海藻、甘草同方配伍的复方中核心药物为昆布、当归、柴胡、夏枯草、牡蛎、陈皮等;核心药对为昆布-甘草,昆布-海藻,当归-海藻,当归-甘草,柴胡-甘草,夏枯草-海藻等;主要治疗的疾病是乳腺和甲状腺疾病等;海藻、甘草的用量分别集中在10～15 g和3～9g;复方中海藻、甘草用药比例在7∶3 ～8∶2.海藻、甘草反药同用常配伍活血化痰药;主要治疗乳腺和甲状腺疾病等;甘草用量小于海藻.

Literature Analysis of Clinical Application of the Compatibility of Sargassum and Radix et Rhizoma Glycyrrhizae in 1949-2009

To explore the features of clinical application of the forbidden incompatible pair of Sargassum and Radix et Rhizoma Glycyrrhizae in one formula recorded in contemporary literatures in the recent 60 years (1949-2009). Relation rules were utilized to release the regulations of their computability, accompanied with statistic analysis of their dosages and primary targeted diseases. The core drugs in the formulas containing the incompatible pair were Thallus Laminariae, Radix Angelicae Sinensis, Radix Bupleuri, Spica Prunellae, Concha Ostreae and Pericarpium Citri Reticulatae; the core drug pairs are Thallus Laminariae-Radix et Rhizoma Glycyrrhizae, Thallus Laminariae-Sargassum, Radix Angelicae Sinensis-Radix et Rhizoma Glycyrrhizae, Radix Angelicae Sinensis-Sargassum. Mastosis and thyopathy are the most common diseases treated by this incompatible pair; the dose of Sargassum and Radix et Rhizoma Glycyrrhizae in the formulas are 10-15 g and 3-9 g respectively; their proportion is usually from 7:3 to 8:2. The forbidden incompatible pair of Sargassum and Radix et Rhizoma Glycyrrhizae is often combined with Chinese medicines for activating blood and resolving phlegm to treat mastosis and thyopathy, and the dose of Radix et Rhizoma Glycyrrhizae is smaller than Sargassum.