丹红注射液联合瑞舒伐他汀对冠心病合并高脂血症患者MFG-E8、Klotho蛋白表达及血脂水平的影响

目的 探究丹红注射液联合瑞舒伐他汀对老年冠心病合并高脂血症患者血清乳脂肪球表皮生长因子-8(MFG-E8)、Klotho蛋白表达及血脂水平的影响.方法 选取冠心病合并高脂血症老年患者86例,根据就诊顺序编号,以随机数字表法分为观察组与对照组,各43例.对照组予以瑞舒伐他汀治疗,观察组予以瑞舒伐他汀+丹红注射液治疗,两组均连续治疗4周.观察统计两组治疗效果、不良反应情况,并比较治疗前后两组血清MFG-E8、Klotho蛋白表达、炎性因子[超敏C反应蛋白(Hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]及血脂[低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)]水平.结果 (1)两组治疗后血脂相关指标水平均较治疗前改善,且观察组LDL-C(3.25±0.70)mmol·L-1、TG(1.70±0.99)mmol·L-1、TC(4.85±0.98)mmol·L-1均低于对照组(3.89±0.92)mmol·L-1、(2.45±1.05)mmol·L-1、(5.56±1.19)mmol·L-1,差异有统计学意义(P<0.05);(2)两组治疗后炎性因子水平均较治疗前改善,且观察组Hs-CRP(4.12±0.94)mg·L-1、TNF-α(0.39±0.25)μg·L-1、IL-6(9.15±2.48)ng·L-1均低于对照组(8.52±2.31)mg·L-1、(0.68±0.34)μg·L-1、(14.32±2.95)ng·L-1,差异有统计学意义(P<0.05);(3)两组治疗后Klotho、MFG-E8蛋白表达水平均较治疗前升高,且观察组Klotho蛋白表达水平(43.25±1.74)ng·L-1、MFG-E8蛋白表达水平(512.38±19.58)mg·L-1均高于对照组(34.85±1.87)ng·L-1、(325.47±12.94)mg·L-1,差异有统计学意义(P<.05);(4)观察组治疗总有效率95.35％(41/43)高于对照组74.42％(32/43),差异有统计学意义(P<0.05);观察组不良反应率20.93％(9/43)与对照组16.28％(7/43)相比,差异无统计学意义(P>0.05).结论 对冠心病合并高脂血症老年患者予以瑞舒伐他汀联合丹红注射液治疗,可有效降低血清Klotho、MFG-E8蛋白表达、血清炎性因子及调节血脂水平,疗效较为显著,且安全性较高.

Effects of danhong injection combined with rosuvastatin on serum MFG-E8,Klotho protein expression and blood lipid level in elderly patients with coronary heart disease complicated with hyperlipidemia

Objective To investigate the effects of Danhong injection combined with rosuvastatin on the expression of epidermal growth factor-8 (MFG-E8),Klotho protein and serum lipid levels in elderly patients with coronary heart disease and hyperlipidemia.Methods 86 patients with coronary heart disease complicated with hyperlipidemia were selected and divided into observation group and control group according to the order of treatment,each group 43 cases.The control group was treated with rosuvastatin and the observation group was treated with rosuvastatin +Danhong injection,the two groups were treated continuously for 4 weeks.Treatment results,adverse re-actions were observed between the two groups.Serum MFG-E8,Klotho protein expression,inflammatory factor [hypersensitive C-reactive protein (Hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6 (IL-6)],and lipid [low density lipoprotein cholesterol (LDL-C), triglyceride (TG),total cholesterol (TC),high density lipoprotein cholesterol (HDL-C)]levels were compared between the two groups before and after treatment.Results (1 )The levels of blood lipid-related indexes in the two groups after treatment were improved com-pared with those before treatment,and the LDL-C level (3.25 ±0.70)mmol·L -1 ,TG level (1 .70 ±0.99)mmol·L -1 and TC level (4.85 ±0.98)mmol·L -1 in the observation group were lower than those in the control group (3.89 ±0.92)mmol·L -1 (2.45 ± 1 .05)mmol·L -1 ,(5.56 ±1 .19)mmol·L -1 .The difference was statistically significant (P <0.05).(2)Inflammatory factor levels in the two groups after treatment were improved compared with those before treatment,and the Hs-CRP level (4.12 ±0.94)mg·L -1 , TNF-α(0.39 ±0.25)μg·L -1 and IL-6 (9.15 ±2.48)ng·L -1 were lower than those in the control group (8.52 ±2.31 )mg· L -1 ,(0.68 ±0.34)μg·L -1 ,(14.32 ±2.95)ng·L -1 ,the difference was statistically significant (P <0.05);(3)The expression of Klotho and MFG-E8 protein in the two groups after treatment were higher than those before treatment,and Klotho protein expression level (43.25 ±1 .74)ng·L -1 ,MFG-E8 protein expression level (512.38 ±19.58)mg·L -1 in the observation group was higher than that of the control group (34.85 ±1 .87)ng·L -1 ,(325.47 ±12.94)mg·L -1 ,the difference was statistically significant (P <0.05);(4)The total effective rate in the observation group 95.35％ (41 /43)was higher than the control group 74.42％ (32 /43), the difference was statistically significant (P <0.05).There was no significant difference in the adverse reaction rate between the ob-servation group 20.93％ (9 /43)and the control group 16.28％(7 /43)(P >0.05).Conclusion The Danhong injection combined with rosuvastatin in treatment of elderly patients with coronary heart disease and hyperlipidemia can effectively reduce the expression of serum Klotho,MFG-E8 protein,serum inflammatory factor and blood lipid level with more significant effect and higher safe.