磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白信号通路参与中枢神经损伤保护与修复的研究进展

中枢神经细胞对各种损伤刺激耐受差,损伤后神经修复困难.因此促进神经保护增强神经再生能力已成为神经治疗关键.磷脂酰肌醇-3磷酸激酶/AKT/雷帕霉素靶蛋白(PI3K/AKT/mTOR)信号通路是调节细胞周期的重要通路,在细胞增殖、生长、分化过程中起中心调控作用,在神经损伤过程中通过激活PI3K/AKT/mTOR信号通路可减少神经细胞死亡,促进神经修复.该文对PI3K/AKT/mTOR信号通路在中枢神经损伤保护作用、修复机制及可能风险作一综述,探讨将PI3K/AKT/mTOR信号通路作为靶点治疗中枢神经疾病.

Progress in the study of the PI3K/AKT/mTOR signaling pathway regulates central nervous damage protection and repair

The central nerve cells are difficult to tolerate of various kinds of damage,and difficult repair after injury.Therefore,it is crucial to promote neural regeneration to nerve protection.The PI3K/AKT/mTOR pathway is an intracellular signaling pathway important in regulating the cell cycle.It plays a central role in cell proliferation,growth and differentiation.The activation of the PI3K/AKT/mTOR signaling pathway can reduce the death of nerve cells and promote nerve repairduring nerve damage.This paper reviewed PI3K/AKT/mTOR signaling pathway in central nervous damage protection,repair mechanisms and possible risksas to exploreuse.The PI3K/AKT/mTOR signaling pathway as a target treatment of central nervous disease.