白细胞介素-35在类风湿关节炎中作用的研究进展

类风湿关节炎(RA)是一种慢性炎症性疾病,疾病晚期可出现关节畸形和功能障碍,严重危害人类健康.RA的确切发病机制目前尚未阐明,遗传、免疫及环境等因素均发挥了一定作用.白细胞介素-35(IL-35)是由人类疱疹病毒4型(HHV-4))又称EB病毒(EBv)诱导基因3(EBI3)和p35两个亚基所组成的异源二聚体蛋白,是白细胞介素-12(IL-12)家族细胞因子成员之一.IL-35由调节性T细胞(Treg)分泌,具有抑制效应T细胞活性的作用,参与多种自身免疫性疾病、炎症性疾病以及感染性疾病的发生和发展.研究发现IL-35与RA之间有重要关系.该文对IL-35在RA的作用方面进行综述.

Research progress on the role of IL-35 in treating rheumatoid arthritis

Rheumatoid arthritis (RA) is a kind of chronic inflammatory disease.Joint deformity and dysfunction can be found in the last stage of the disease,which is harmful to human health.The exact pathogenesis of RA has not yet been elucidated,however,it is known that there are genetic,immune and environmental factors.Interleukin 35 (IL-35) is a heterodimer protein,which is composed of p35 and human herpes virus 4 (HHV-4),also called Epstein-Barr virus-induced gene 3 (EBI3) subunits.It is one of the cytokine members of interleukin 12 (IL-12) family.Secreted by regulatory Tcells,IL-35 suppresses the activity of effector Tcells and participates in the occurrence and development of various autoimmune,inflammatory,and infectious diseases.A large number of studies have found that there is an important relationship between IL-35 and RA.This paper mainly summarizes the role of IL-35 in treating RA.