一起原因不明食物中毒的调查和实验室筛查

[目的 ]　探讨一起原因不明食物中毒的中毒原因。 [方法 ]　应用病例对照研究方法和简易急性动物试验等方法 ,对不明原因食物中毒的致病因素进行多方面探讨。 [结果 ]　由病例对照研究筛选出水煮豆腐是本次中毒的可疑食物 ;急性动物试验验证了水煮豆腐是唯一有毒食物 ,小白鼠的灌注量与中毒反应呈剂量反应关系 ,小白鼠对水煮豆腐的半数致死剂量为LD50 =1.6 8mg/g体重。经气相色谱—质谱仪分析鉴定毒物为四次甲基二砜四胺。[结论 ]　该起事故是由于食用了被四次甲基二砜四胺污染的水煮豆腐引起的食物中毒 ,研究方法可用于食物中毒及其他突发事件

Epidemic research and experimental screening on an episode of food poisoning

Objective] To determine the cause of an episode of food posionig. [Methods] A case-control study was carried out together with acute animal toxicological experiments of 7 sorts of the food. [Results] The responsible food was boiled Doufu. The LD 50 of mice was 1.68mg/g. Tetramine was found in the food by GC/MC that the etiology was successfully defined.[Conclusion] Case-control study and toxicological examination are useful in analysis of food poisoning, and may be used in other accidents or intoxication.