甲基强的松龙治疗小儿喘息性疾病急性发作疗效分析

目的 :为小儿喘息性疾病急性发作寻找快捷、高效的控制发作全身抗炎药物。方法 :70例中、重度喘息性疾病急性发作患儿随机分为二组 ,A组甲基强的松龙 2mg/ (kg 次 ) ,B组地塞米松 0 5mg/ (kg 次 ) ,两组均 8h一次静脉输注 ,2 4h后每 12h一次 ,连用 3天 ,并同时空气压缩雾化吸入沙丁胺醇溶液。治疗后 2 4h及治疗后第 4天对临床症状改善情况进行评分 ,按积分进行疗效评价。结果 :治疗 4d后积分A组 1 41分 ,B组 3 13分 ,两组有显著差异 (P <0 0 1) ;临床控制率分别为 2 7 5 %、13 3% ;显效分别为 6 5 0 %、5 3 3% ,两组之间差异显著 (P均 <0 0 5 )。结论 :甲基强的松龙能控制气道炎症、缓解哮喘急性发作 ,不良反应较少 ,是较为理想的全身糖皮质激素

Analysis of efectiveness of methylpredinisolone on acute onset of chil dren''''s asthmatic diseases

Objective:To look out a quick and effective method to control acute onset in children's asthmatic diseases with medicine Methods:70 Cases of middle and severe asthmatic diseases were randomly divided into two groups,group A were given methylpredinisolone 0 2 mg/kg per dosage and group B,dexmethasone 0 5 mg/kg per dosage One time every 8 hour in the first day and then every 12 hours in the second and third day through vein infusion,at the same time,salbutamol solution was inhaled through air-compression pump in both two groups The improvement of symptoms were observed and made scores to evaluate the effectiveness respectively after 24 hours and 4 days therapy Results:The scores were respectively 1 41 and 3 13 after 4 days therapy,which showed a signifincantly difference in two groups ( P <0 01) The control rate were respectively 27 5% and 13 3% ( P <0 05),and the effectiveness rate 65 0% and 53 3% ( P <0 05) There was a signifincantly difference in two groups Conclusions:Methylpredinisolone is an ideal medicine to control airway inflammation and releave the acute asthmatic diseases