Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria |
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Authors: | Stoelcker Benjamin Hehlgans Thomas Weigl Karin Bluethmann Horst Grau Georges E Männel Daniela N |
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Affiliation: | Institute of Pathology/Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany. |
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Abstract: | Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria. |
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