雌、孕激素受体在肝门部胆管癌中的表达及意义

目的探讨雌、孕激素受体（ER、PgR）在肝门部胆管癌的表达情况,研究它们的表达与肿瘤的病理类型、分级及临床分期的关系。方法应用免疫组织化学法,检测42例肝门部胆管癌组织中ER及PgR的表达水平。结果在肝门部胆管癌中ER及PgR阳性表达率分别为66.7％和64.3％。高分化型与低分化型之间及乳状型与硬化型之间ER及PgR表达具有明显差异。结论ER及PgR在肝门部胆管癌中的表达率较高。ER及PgR可能有希望成为反映肝门部胆管癌恶性程度和预后的一项生物学指标。

Expression of estrogen receptor and progesterone receptor in hilar cholangiocarcinoma and their clinical significances

Objective To investigate the relationship between the expression of estrogen receptor (ER) and progesterone receptor (PgR) and histological type, pathological grading and clinical staging in hilar cholangiocarcinoma (HCCA). To evaluate their roles in the development of it. Methods ER and PgR were assessed in 42 specimens of HCCA by immunohistochemical assay. Results The positive rate of ER and PgR was 66.7% and 64.3%. The expression of ER and PgR was significantly different between poor and well tumor differentiation, as well as between papillary and sclerosing variant. Conclusion The positive rate of ER and PgR was detected significantly in HCCA. They might be an important biological marker to evaluate the malignancy and prognosis of it.