| 中药复方新药创制及技术支撑体系 |
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| 引用本文： | 梁琼麟,罗国安,邹健强,高秀梅,刘建勋,叶祖光,贾伟. 中药复方新药创制及技术支撑体系[J]. 世界科学技术-中医药现代化, 2008, 10(3): 1-7 |
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| 作者姓名： | 梁琼麟 罗国安 邹健强 高秀梅 刘建勋 叶祖光 贾伟 |
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| 作者单位： | 清华大学中药现代化研究中心,北京,100084;科技部社会发展司生物医药处,北京,100862;天津中医药大学,天津,300193;中国中医科学院西苑医院,北京,100091;中药复方新药开发国家工程研究中心,北京,100075;上海交通大学药学院,上海,200030 |
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| 基金项目： | 国家“十一五”科技支撑计划(2006BAI08B04):中药复方作用和配伍评价研究 |
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| 摘 要： | 随着人类疾病谱的变化,复方药物日益得到包括国际主流医药界的重视和认可.中医药以其在慢性复杂多因素性疾病的治疗方面具有的显著优势备受关注.以确有疗效的中医方剂和名优中成药为源头,研究开发成为中医药特色明显、配伍科学合理、药效成分基本清楚、机理基本明确、安全有效、质量可控的复方中药创新药,有望国际主流医药市场的认可,并在未来创新药物国际竞争中占据有利地位.本文根据中医药的特点提出了中药复方新药创制的技术路线,对其技术支撑体系的建设提出了有关建议和方案,并对中药复方新药创制的发展趋势和方向进行了展望.
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| 关 键 词： | 新药发现 新药开发 中药 复方药物 技术路线 关键技术 |
| 收稿时间： | 2008-04-29 |
| 修稿时间： | 2008-05-14 |
Strategy and Technical Support System for Developing New TCM Drugs |
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| Liang Qionglin,Luo Guoan,Zou Jianqiang,Gao Xiumei,Liu Jianxun,Ye Zuguang and Jia Wei. Strategy and Technical Support System for Developing New TCM Drugs[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2008, 10(3): 1-7 |
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| Authors: | Liang Qionglin Luo Guoan Zou Jianqiang Gao Xiumei Liu Jianxun Ye Zuguang Jia Wei |
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| Affiliation: | Modern Research Center for TCM; Tsinghua University; Beijing 100084;Modern Research Center for TCM; Tsinghua University; Beijing 100084;Division of Biotechnology and Medicine; Department of Social Development; Ministry of Science and Technology of China; Beijing 100862;Tianjin University of Traditional Chinese Medicine; Tianjin 300193;Xiyuan Hospital; China Academy of Chinese Medical Sciences; Beijing 100091;State Research Center for R&D of TCM Multi-ingredient Drugs; Beijing 100075;School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200030 |
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| Abstract: | Along with frequently changed human disease spectrums,muhi-component drugs have attracted increasing atten- tion of the mainstream international medical community.Traditional Chinese Medicine (TCM) has been deemed one of the best choices for treating complex chronic diseases.In this context,people believe that TCM formula and Chinese patented medicines with proven effects are valuable assets for bringing out new drugs,and that modernized composite medicine (MCM) can be developed enjoying TCM-specific merits... |
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| Keywords: | new drug discovery/development Traditional Chinese Medicine composite medicine/multi-component drug routine key technology |
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