| 葛根素对心肌梗死大鼠心肌iNOS，eNOS蛋白表达及AKT磷酸化水平的影响 |
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| 引用本文： | 杨惊宇,杨鹏,张三印.葛根素对心肌梗死大鼠心肌iNOS，eNOS蛋白表达及AKT磷酸化水平的影响[J].世界科学技术-中医药现代化,2008,10(3):43-47. |
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| 作者姓名： | 杨惊宇 杨鹏 张三印 |
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| 作者单位： | 深圳市宝安中医院,深圳518133;成都市第五人民医院,成都611130;成都中医药大学,成都610075 |
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| 基金项目： | 香港赛马会慈善基金:葛根素及其相关产品的应用与研究 |
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| 摘 要： | 目的:探讨葛根素诱导血管生成的分子机制.方法:通过大鼠心肌梗死动物模型,运用Western-blot的方法检测心肌iNOS、eNOS,AKT,p-AKT的蛋白表达.结果:葛根素120mg/kg腹腔注射四周能不同程度增加心肌梗死大鼠缺血区域和非缺血区域心肌eNOS蛋白表达以及AKT磷酸化水平,而对iNOS蛋白表达没有明显的影响.结论:葛根素诱导血管生成作用的分子机制与其促进AKT磷酸化水平,从而激活eNOS,使NO生成增加有关.
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| 关 键 词： | 血管生成 葛根素 eNOS iNOS AKT |
| 收稿时间： | 3/5/2008 12:00:00 AM |
| 修稿时间： | 4/7/2008 12:00:00 AM |
The Effects of Puerarin on Myocardial Enos,Inos Protein Expression and AKT Protein Phosphorylation Level in Rats with Myocardial Infarction |
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| Yang Jingyu,Yang Peng and Zhang Sanyin.The Effects of Puerarin on Myocardial Enos,Inos Protein Expression and AKT Protein Phosphorylation Level in Rats with Myocardial Infarction[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2008,10(3):43-47. |
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| Authors: | Yang Jingyu Yang Peng and Zhang Sanyin |
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| Institution: | Shenzhen Bao\'an Hospital; Shenzhen 518133;Chengdu No.5 People\'s Hospital; Chengdu 611130;Chengdu TCM University.Chengdu; 610075 |
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| Abstract: | This is a study of puerarin and its angiogenesis mechanism at the molecular level.In the study,a rat myocardial infarction model,and the Western-Blot approach were applied to detect protein expressions of myocardial eNOS, iNOS,AKT,and p-AKT.Study results show that Puerarin (120mg/kg,i.p.) is able to increase protein expressions of myocardial eNOS,and raise the AKT protein phosphorylation level in the rats with a myocardium infarction,without significant differences in iNOS protein expression.It is concluded... |
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| Keywords: | angiogenesis puerarin eNOS iNOS AKT |
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