| 金银花体外抗结核活性研究 |
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| 引用本文： | 邱 葵,刘宇红,孔繁翠,赵 兵,顾 昊,徐佳佳,王鹤尧.金银花体外抗结核活性研究[J].世界科学技术-中医药现代化,2009,11(6):876-879. |
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| 作者姓名： | 邱 葵 刘宇红 孔繁翠 赵 兵 顾 昊 徐佳佳 王鹤尧 |
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| 作者单位： | 首都医科大学附属北京朝阳医院药事部,北京,100020;北京市结核病胸部肿瘤研究所,北京,101149;首都医科大学附属北京朝阳医院药事部,北京,100020;北京市结核病胸部肿瘤研究所,北京,101149;首都医科大学附属北京朝阳医院药事部,北京,100020;首都医科大学附属北京朝阳医院药事部,北京,100020;首都医科大学附属北京朝阳医院药事部,北京,100020 |
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| 摘 要： | 目的：探讨金银花体外抗结核活性。方法：使用试管倍比稀释法测定金银花、绿原酸、异烟肼对结核分支杆菌标准株和金色分支杆菌的最小抑菌浓度（Minimum Inhibitory Concentration，MIC）及最小杀菌浓度（Minimum Bactericidal Concentration，MBC）。结果：金银花对金色分支杆菌的MIC为0.83mg?mL-1，MBC为1.75mg?mL-1，对H37Rv的MIC、MBC均为0.18mg?mL-1；绿原酸对两种分支杆菌的MIC、MBC均为0.18mg?mL-1；异烟肼对两种分支杆菌的MIC、MBC均为10.5?滋g?mL-1，异烟肼配伍金银花使用，异烟肼对两种分支杆菌的MIC、MBC为5.25?滋g?mL-1。结论：金银花有抗结核活性。同异烟肼联合使用能显著降低异烟肼的MIC和MBC。
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| 关 键 词： | 金银花 结核分支杆菌 金色分支杆菌 最小抑菌浓度（MIC） 最小杀菌浓度（MBC） |
| 收稿时间： | 8/6/2009 12:00:00 AM |
| 修稿时间： | 2009/12/4 0:00:00 |
Antituberculosis Activities in Vitro of Flos Lonicerae |
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| Qiu Kui,Liu Yuhong,Kong Fancui,Zhao Bing,Gu Hao,Xu Jiajia and Wang Heyao.Antituberculosis Activities in Vitro of Flos Lonicerae[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2009,11(6):876-879. |
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| Authors: | Qiu Kui Liu Yuhong Kong Fancui Zhao Bing Gu Hao Xu Jiajia and Wang Heyao |
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| Institution: | Department of Pharmacology, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China ; 2. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;Department of Pharmacology, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China ; 2. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;Department of Pharmacology, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China ; 2. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;Department of Pharmacology, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China ; 2. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China;Department of Pharmacology, Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences, Beijing 100020, China ; 2. Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China |
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| Abstract: | |
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| Keywords: | Flos lonicerae M tuberculosis M aurum MIC MBC |
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