| 感冒药YL2000水煎与醇提物中挥发性成分GC-MS的分析比较——从提取工艺对现代中药的思考 |
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| 引用本文： | 马超,王伟,李伯男,花雷,邢东明,王玉刚,杜力军.感冒药YL2000水煎与醇提物中挥发性成分GC-MS的分析比较——从提取工艺对现代中药的思考[J].世界科学技术-中医药现代化,2008,10(2):78-82. |
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| 作者姓名： | 马超 王伟 李伯男 花雷 邢东明 王玉刚 杜力军 |
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| 作者单位： | 清华大学生物科学与技术系药物药理研究室,北京100084;清华大学生物科学与技术系药物药理研究室,北京100084 |
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| 基金项目： | 清华大学科技攻关项目(Fd038)抗感染有效中药及其活性成分的研究; 国家十一五科技支撑计划(2006BAI08B03-09)中药复方质量控制与评价方法研究 |
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| 摘 要： | 目的:研究感冒药YL2000现代制剂中的挥发性成分,考查比较水煎与醇提工艺对复方挥发性成分的影响.方法:水蒸气蒸馏法提取挥发性成分,GC-MS法进行分析鉴定,峰面积归一法测定各成分的相对含量,并与水煎剂的挥发性成分进行对比.结果:从YL2000醇提制剂中初步分离鉴定了68个成分;同水煎剂相比,醇提制剂提高了挥发油的得率,去除了大量脂肪酸类成分,但保留了水煎剂中的88%的萜类成分,并将其含量提高了约6倍;同单味药材相比,醇提制剂和水煎剂均富集了萜类成分而大大降低了蒎烯和蒈烯类成分的含量.结论:YL2000醇提制剂保留了水煎降低蒎烯和蒈烯含量的特点,而且进一步富集了水煎剂中的萜类有效成分,降低了脂肪酸类成分.
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| 关 键 词： | 挥发油 醇提物 水煎剂 气相色谱 质谱 |
| 收稿时间： | 2007/12/20 0:00:00 |
| 修稿时间： | 2008/1/25 0:00:00 |
A GC-MS based Comparative Study of YL2000 Ethanol Decoction Oils |
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| Ma Chao,Wang Wei,Li Bonan,Hua Lei,Xing Dongming,Wang Yugang and Du Lijun.A GC-MS based Comparative Study of YL2000 Ethanol Decoction Oils[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2008,10(2):78-82. |
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| Authors: | Ma Chao Wang Wei Li Bonan Hua Lei Xing Dongming Wang Yugang and Du Lijun |
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| Institution: | Laboratory of Pharmaceutical Sciences; Department of Biological Sciences and Biotechnology; Tsinghua University; Beijing 100084; China;Laboratory of Pharmaceutical Sciences; Department of Biological Sciences and Biotechnology; Tsinghua University; Beijing 100084; China |
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| Abstract: | Authors analyzed the essential oils derived from YL2000 ethanol decoction,and investigated the differences be- tween the essential oils derived from water decoctions and from the four herbs.The essential oils of YL2000 ethanol decoction were extracted by water-steam distillation,and separated/identified by GC-MS.The components were calcu- lated using the normalization approach,and compared against the reference.68 compounds have been identified. Comparing with the water decoction,fatty acids were reduced,wh... |
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| Keywords: | YL2000 essential oils ethanol extract water decoction GC-MS |
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