| 系统生物学在中药复方研究中的应用 |
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| 引用本文： | 窦圣姗,柳润辉,姜鹏,张川,张卫东,刘磊,罗国安. 系统生物学在中药复方研究中的应用[J]. 世界科学技术-中医药现代化, 2008, 10(2): 116-121 |
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| 作者姓名： | 窦圣姗 柳润辉 姜鹏 张川 张卫东 刘磊 罗国安 |
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| 作者单位： | 第二军医大学药学院,上海,200433;湖南中医药大学,长沙,41007;清华大学化学系生命有机磷与化学生物学教育部重点实验室/清华大学生命科学与医学研究院中药现代化研究中心,北京,100084 |
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| 基金项目： | 科技部“十一五”支撑计划项目(2006BAI08804-1)中药复方作用机理和中药复方配伍评价方-化学物质组学的整体系统生物学研究; 教育部2007年新世纪优秀人才支持计划(NCET) 上海市科委中药现代化专项(070219702-1)“麝香保心丸”系统生物学研究 |
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| 摘 要： | 中药复方的现代化一直是中医药界多年来关注的焦点.由于中药复方多成分、多靶点的作用特点,其作用物质及机理研究一直处于"知其然,不知其所以然"的尴尬地位,无法进行科学、全面、准确的阐述.系统生物学的提出,为中药复方的研究提供了崭新的思路和方法,成为当今中药研究中的热点领域.系统生物学从整体观出发,系统研究中药复方的药效物质基础、配伍规律、广泛的药理及其作用机理,为打破长久以来困扰中医药研究的"黑匣"问题提供了契机.本文对系统生物学的思路、方法及其在中药复方研究中的应用与发展进行了综述和评价.
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| 关 键 词： | 系统生物学 中药复方 应用 |
| 收稿时间： | 2007-09-17 |
| 修稿时间： | 2007-11-25 |
System Biology and Its Application in TCM Formula Study |
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| Dou Shengshan,Liu Runhui,Jiang Peng,Zhang Chuan,Zhang Weidong,Liu Lei and Luo Guoan. System Biology and Its Application in TCM Formula Study[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2008, 10(2): 116-121 |
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| Authors: | Dou Shengshan Liu Runhui Jiang Peng Zhang Chuan Zhang Weidong Liu Lei Luo Guoan |
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| Affiliation: | 1School of Pharmacy; Second Military Medical University; Shanghai 200433;1School of Pharmacy; Second Military Medical University; Shanghai 200433;1School of Pharmacy; Second Military Medical University; Shanghai 200433;1School of Pharmacy; Second Military Medical University; Shanghai 200433;1School of Pharmacy; Second Military Medical University; Shanghai 200433;Hunan University of Traditional Chinese Medicine; Changsha 41007;Key Lab of Chemical Biology under Ministry of Education Department of Chemistry; Tsinghua University; Modem Research Center of TCM; Institute of Biomedicine; Beijing 100084 |
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| Abstract: | The development of traditional Chinese medicine (TCM) formula in a modernized context has been an endeavor of the TCM industry for many years,though TCM has not yet been understood in a clear manner of its physical basis and mechanism,due to its multi-component and multi-targets nature.Fortunately,system biology is in a position to pro- vide novel insights for TCM study.This means,some difficult spots of TCM formula study,including the physical basis of TCM therapeutic effects,compatibility,pharmacology and... |
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| Keywords: | system biology traditional Chinese medicine formula |
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