局部放疗联合89Sr治疗骨转移癌的疗效观察

目的评价局部放疗配合放射性核素^89Sr治疗骨转移癌的疗放，分析单纯放疗单纯核素^89Sr治疗及联合治疗的副作用。方法观察60例确诊为骨转移癌的患者，分为3组，每组20例。局部放疗（A组），采用6MV直线加速器外照射给予吸收剂量30—60Gy，2—4周，局部放疗＋^89Sr治疗（B组），单纯^89Sr治疗（C组）放射性核素^89Sr静脉内注射3—4mCi。结果治疗后B组骨痛缓解，原发灶改善明显好于A、C组；新增疼痛部位及转移灶均少于A、C组（P〈0．05）。治疗后血液学的毒性3组差异统计学意义（P〉0．05）。结论局部放疗配合^89Sr治疗骨转移癌有较好的疗效，提示对单发性骨转移患者的压痛明显部位给予局部外照射止痛效果明显，对多发骨转移且病灶相距较近的给予放疗联合^89Sr治疗效果安全可靠，对全身性多发性骨转移者采用单纯放射性核素^89Sr治疗对于止痛和控制骨转移有一定疗效。

Observing of the effects on combination with local radiotherapy and radio-nuclides 89Sr to treat bone metastasis cancer

Objective To evaluate the effects on local radiotherapy and radio_nuclides ~ 89 Sr to treat cancer with bone metastasis, analyze the simple radiotherapy treatment and the treatment of side effects of radio_nuclide ~ 89 Sr. Methods 60 patients,who were bone metastasis cancers,divided into 3 groups: local radiotherapy (A group), 6 MV linear accelerator external irradiation dose given 30_60 Gy/2_4 weeks, local radiotherapy and ~ 89 Sr treatment (B group), ~ 89 Sr treatment (C group), intravenous injection 3_4 mCi. Results After treatment, B group's bone pain was relieved.B group's primary sites was significant improvement than A and C from bone imaging shown,new pains and metastases sites lower than others.There was no significant difference in toxicity of blood among three groups (P>0.05). Conclusions Local radiotherapy combined with ~ 89 Sr meght be an effective treatment for bone metastasis cancer.It is suggested that the pain relieve effect of local external radiotherapy on single bone metastasis location was remarkable.It is safe and reliable to perform radiotherapy and ~ 89 Sr combination treatment for multiple bone metastasis in close proximity.And it has certain effects to carry out ~89 Sr treatment for whole-body multiple bone metastases.;