非依赖性药物治疗海洛因成瘾的临床研究(附700例报道)

目的 为研究非依赖药物治疗海洛因成瘾，采用卡马西平和泰必利，按一定比例混匀配制成胶囊（以下称胶囊）治疗戒毒者的戒断症状。方法 用于临床前，委托贵阳医学院药理教研室进行了动物药理和毒理试验。结果 该胶囊能消除在小鼠对吗啡和海洛因依赖的戒断症状；大小鼠对胶囊无依赖性；急性和长期毒性试验表明无毒性作用。单用该胶囊治疗７００例自愿戒毒者，疗程７～１５天，随方３个月，采取自身对照法，比较戒毒者治疗前后的症状

Clinical study on non-depended drug treatment of heroin addiction

Objective To study nondepended drug for treatment of heroin addiction.Methods A mixture of carbamagepine and tiapridum capsules medicine were administed to treat abstinence symptoms of heroin addicts. pharmacological and toxicological on animals were tested.Results The mixture capsule could rid of abstinence symptoms of addicted animals to heroin and morphia. Test animals was nondepended to mixture capsules.The capsules was not toxicity of longer and shoutterm to text animals. 700 volunteer addicted patients were treated with the capsules course of treatment 715 days and 3 months followup. The results shown that capsules was satisfactorily effective, safe and without any serious sidseffects.Conclusion The capsules could be well used maintainingtreatment acuteaddition, and family detoxification treatment.