| 心脏靶向超声造影剂空气白蛋白微球的研究(2)制备化学原理研究 |
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| 引用本文： | 侯连兵,陈树元.心脏靶向超声造影剂空气白蛋白微球的研究(2)制备化学原理研究[J].中国生化药物杂志,1999,20(2):65-67. |
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| 作者姓名： | 侯连兵 陈树元 |
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| 作者单位： | 第一军大学南方医院药学部!广州510515 |
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| 摘 要： | 探索声振制备空气白蛋白微球的化学原理。方法：用化学发光监测声振白蛋白溶液时产生氧自由基的过程，并用飞行时间质谱分析声振前后白蛋向分子的变化。结果：声振白蛋白溶液产生大量氧自由基；化学发光值与微球数量呈正相关性；声振使白蛋白分子产生电荷改变。结论：声振产生氧自由基使白蛋白分子的空间结构发生逆性的变化。
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| 关 键 词： | 白蛋白微球 制备 氧自由基 化学发光 飞行质谱 |
Study on Air-filled Albumin Microspheres: an Echo-contrast Agent for Heart Targeting (2). Chemical Mechanism of the Preparation |
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| Hou Lianbin. Chen Shuyuan,Jin Weijun,Shan Youliang,Zhou Rihong,Chen Zhiliang.Study on Air-filled Albumin Microspheres: an Echo-contrast Agent for Heart Targeting (2). Chemical Mechanism of the Preparation[J].Chinese Journal of Biochemical Pharmaceutics,1999,20(2):65-67. |
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| Authors: | Hou Lianbin Chen Shuyuan Jin Weijun Shan Youliang Zhou Rihong Chen Zhiliang |
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| Abstract: | Purpose The aim was to study the chemical mechanism of air-filled albumin microspheres prepared by sonication. Methods: Chemilluminescence was used to measure oxyen free radicals induced by sonication on the albumin solution, laser time-flight mass spectrum was used to analyze the changes of albumin molecule sonicated. Resutls; The acoustic sonication in water generated large of oxygen free radicals, which was in positive relation with the concentration of air - filled albumin microspheres. Laser time-flight mass spectra showed that sonication caused albumin molecule to carry more positive electrical charges. Conclusion: The acoustic sonication only caused reversible changes in spatial structure of albumin molecule. |
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| Keywords: | Air-filled albumin microsphere Preparation Oxygen free radical Chemiiuminecence Laser time flight mass spectrum |
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