加味玉屏风散治疗儿童过敏性紫癜的临床研究

目的：探讨中西医结合治疗儿童过敏性紫癜（HSP）的临床效果。方法：选取2010年3月-2014年3月本院收治的90例确诊为HSP的患儿，按随机数字表法分为观察组46例和对照组44例，对照组行常规西医治疗，观察组在对照组基础上加用加味玉屏风散治疗。对比两组患儿的临床疗效及IL-5和IL-10水平。结果：观察组总有效率为95.7%，治愈率为82.6%，住院时间为（7.5±1.5）d；对照组分别为77.3%、50.0%、（8.5±2.1）d。两组上述指标比较差异均有统计学意义（P〈0.05）。治疗3个月后两组的血清IL-5水活性水平明显下降，IL-10活性水平明显上升，且观察组较对照组下降或上升更明显，差异均有统计学意义（P〈0.05）。结论：中西医结合的综合疗法治疗HSP可显著提高患儿的治愈率和有效率，缩短病程，提高患儿的生命质量，可进一步推广应用。

Clinical Study of Modified Yupingfeng San in Treating Children Allergic Purpura

Objective：To investigate the clinical effect of the combination of traditional Chinese and Western medicine treatment on children with allergic purpura（HSP）.Method：90 patients with HSP in our hospital from March 2010 to March 2014 were selected,and randomly divided into 46 cases in the observation group and 44 cases in the control group,the control group were given conventional western medicine treatment,based on the control group,the observation group were given modified Yupingfeng San treatment,the clinical curative effect and the IL-5 and IL-10 levels two groups were compared.Result：In the observation group,the total effectiveness was 95.7%,the cure rate was 82.6%,hospitalization time was（7.5±1.5）d;in the control group respectively were 77.3%,50.0%,（8.5±2.1）d. The differences of above indicators between the two groups had statistically significant（P〈0.05）. After 3 months treatment, the serum IL-5 activity significantly decreased,IL-10 activity significantly increased,and the observation group decreased or increased more significantly than in the control group,there were statistically significant differences（P〈0.05）. Conclusion：Combined therapy of Chinese and Western medicine to treat allergic purpura can significantly improve the cure rate and efficiency of children,shorten the course of disease,improve the quality of life in children,can be further applied.