浅析颅内肿瘤术中应用舒芬太尼联合雷米芬太尼的麻醉效果

目的：分析研究颅内肿瘤术中应用舒芬太尼联合雷米芬太尼的麻醉效果，旨在提高颅内肿瘤术的麻醉水平。方法：选取本院2012年5月-2013年5月收治的84例需实施颅内肿瘤切除术的患者，按照随机数字表法将其分为雷米芬太尼组、舒芬太尼组和舒芬太尼联合雷米芬太尼组，每组28例患者。三个小组在麻醉诱导上没有任何区别；在麻醉维持上，雷米芬太尼组与舒芬太尼联合雷米芬太尼组在插管之后都采取静脉泵注的方式，持续供给该组患者0.2μg/（kg·min）雷米芬太尼。舒芬太尼组则要在患者切皮之前对其注射0.1-0.15μg/kg的舒芬太尼。此外，对所有患者的SpO2、BIS、ETCO2、HR、MBP等指标进行术中监测与分析。同时，对三组患者的T1（呼吸恢复时间）、T2（睁眼时间）、T3（拔管时间）等进行比较。结果：三组患者的手术时间等一般情况比较差异无统计学意义（P〉0.05）。三组患者在各个时间点所监测到的SpO2、BIS、ETCO2、HR、MBP值均无统计学意义（P〉0.05）。舒芬太尼联合雷米芬太尼小组的舒芬太尼用量明显少于舒芬太尼组，其雷米芬太尼的用量也明显少于雷米芬太尼组，比较差异均有统计学意义（P〈0.01）。术后，雷米芬太尼组与舒芬太尼联合雷米芬太尼组患者的呼吸恢复时间、睁眼时间、拔管时间比较差异无统计学意义（P〉0.05），但是这两组均明显低于舒芬太尼组，差异均有统计学意义（P〈0.01）。结论：在颅内手术中舒芬太尼联合雷米芬太尼的麻醉效果优于这两种药品单独使用的麻醉效果，不良反应少，苏醒快，并且效果稳定，适合在临床中推广。

Analysis on the Anesthesia Effects on the Application of Sufentaull and Remifentanil on Intracranial Tumor Resection

Objective：To analyze the anesthesia effects on the application of sufentanil and remifentanil on intracranial tumor resection,to improve the level of anesthesia in intracranial tumor surgery.Method：Eighty-four patients with intracranial tumor resection were selected in our hospital from May 2012 to May 2013,they were randomly divided into the remifentanil group,the sufentanil group and sufentanil combined remifentanil group,28 cases in each group.Three groups during anesthesia induction had no difference.In the maintenance of anesthesia,remifentanil group and sufentanil combined remifentanil group were treated with the intravenous infusion therapy,continuous supplied the group of patients with 0.2μg/（kg·min） remifentanil.The sufentanil group before skin incision in patients were injected 0.1-0.15μg/kg sufentanil.In addition,the intraoperative of all patients with SpO2,BIS,ETCO2,HR,MBP index were monitored and analyzed.At the same time,the T1（breathing recovery time）,T2（open time）,T3（extubation time）of the three groups were compared.Result：Operation time and so on general situation of three groups of patients compared differences no statistical significance（P〉0.05）. SpO2,BIS,ETCO2,HR,MBP values of three groups at all time points had no statistical significance（P〉0.05）. The dosage of sufentanil in sufentanil combined remifentanil group was significantly less than that in the sufentanil group,and the remifentanil dosage was less than that in the remifentanil group,the differences were statistically significant（P〈0.01）. After operation,there had no significant difference for remifentanil group and sufentanil combined remifentanil group patients in respiratory recovery time,eye opening time,extubation time,but the two groups were significantly lower than that in the sufentanil group,the differences were statistically significant（P〈0.01）.Conclusion：Anesthesia effect on sufentanil combined remifentanil group in intracranial operation is better than the anesthetic effect of these two kinds of drug used alone, less adverse reaction,faster recovery,the effect is stable,and suitable for promotion in clinic.