间断和“持续”血液灌流治疗急性百草枯中毒的疗效观察

目的：观察间断和“持续”血液灌流对急性百草枯中毒患者的临床疗效。方法：回顾性研究本院急性百草枯中毒患者59例，所有患者均采用内科常规综合治疗，分为A组26例采用间断血液灌流，B组33例采用“持续”血液灌流，根据患者预后又分为死亡组和存活组。结果：A、B两组患者性别、年龄、服药剂量、服药后至人院治疗时间比较差异无统计学意义（P〉0．05）；A、B两组患者治疗疗效比较差异无统计学意义（P〉0．05），B组死亡患者存活时间长于A组（P〈0．05）；与存活组相比，死亡组服药剂量明显增高。结论：间断和“持续”血液灌流对于百草枯中毒患者疗效相同，“持续”血液灌流能明显延长中毒死亡患者的存活时间，中毒患者死亡因素主要与患者服用百草枯剂量有关。

The Clinical Effect of Intermittent and Continuous Hemoperfusion in the Treatment of Acute Paraquat Poisoning

Objective： To assess the clinical effects of intermittent and continuous hemoperfusion on acute paraquat poisoning. Method： 59 patients with acute paraquat poisoning were randomly divided into two groups, A group composed of 26 patients were treated with intermittent hemoperfusion and continuous hemoperfusion was administered in B group composed of 33 patients. All patients were treated with conventional medication, then, According to the prognosis of the patients was divided into death group and survival group. Result： There were no significant difference in Gender, age, the toxic dose, and after the poisoning to hospitalization time between the two groups （ P〉0.05 ） . Therapeutic effect of the A and B group had no difference （ P〉0.05 ） . The survival time of death patients in the B group was longer than that of death patients in the A group （ P〈0.05 ） . Compared with the survival group, the toxic dose was higher significantly in death group. Conclusion： There is no difference in the clinical efficacy between intermittent and continuous hemoperfusion on acute paraquat poisoning, continuous hemoperfusion can prolong the survival time of death obviously, the main causes of death is related to the toxic dose.