| 沉默VEGF基因对腺样囊性癌细胞侵袭的影响 |
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| 引用本文： | 黄燕婷,劳均平.沉默VEGF基因对腺样囊性癌细胞侵袭的影响[J].现代保健,2014(12):37-38. |
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| 作者姓名： | 黄燕婷 劳均平 |
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| 作者单位： | 广东省佛山市第一人民医院,广东佛山528000 |
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| 基金项目： | 广东省医学科研基金（B2011302） |
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| 摘 要： | 目的：利用RNAi技术沉默腺样囊性癌细胞株ACC-2中VEGF的表达，探讨其对肿瘤细胞侵袭能力的影响。方法：利用RNAi技术沉默VEGF表达，用Transwell侵袭实验检测细胞体外侵袭能力的变化。结果：与对照组比较，VEGF的siRNA能有效地抑制实验组ACC-2细胞的侵袭能力。结论：沉默VEGF减弱腺样囊性癌的侵袭能力。
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| 关 键 词： | 涎腺腺样囊性癌 血管内皮生长因子 RNA干扰 侵袭 |
The Study of the Influence on Invasiveness Activity of ACC-2 Cells Via RNAi VEGF |
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| Authors: | HUANG Yan-ting LAO Jun-ping |
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| Institution: | (The First People＇s Hospital of Foshan City, Foshan 528000, China) |
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| Abstract: | Objective：To investigate the inhibitory effects of VEGF targeted small interference RNA（siRNA）on invasiveness of salivary adenoid cystic carcinoma（SACC）cell line ACC-2. Method：VEGFsiRNA was transfect into SACC cell line ACC-2 and then examine the changes of invasive ability of ACC-M. Result：The invasive and proliferative abilities of ACC-2 decreased,and the difference between the two groups were statistically significant（P＆lt;0.05）. Conclusion：Si-VEGF can effectively decrease invasiveness of SACC cells. |
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| Keywords: | Salivary adenoid cystic carcinoma Vasculare endothelial growth factor RNA interference Invasiveness |
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