抗结核药所致药物性肝炎应用多烯磷脂酰胆碱治疗的疗效

目的：探究抗结核药所致药物性肝炎应用多烯磷脂酰胆碱治疗的疗效。方法：选取2011年10月-2013年10月在本院诊治的抗结核药所致药物性肝炎患者96例，按照随机数字表法将患者分成两组，每组48例，对照组予肌苷、肝泰乐和门冬氨酸钾镁治疗，研究组联合多烯磷脂酰胆碱治疗，分析两组临床疗效、症状改善和肝功能的相关指标变化情况。结果：治疗后研究组的总有效率为93.75%，对照组为79.17%，两组比较差异有统计学意义（P＜0.05）。研究组尿黄、皮肤巩膜的黄染分别为6.25%、10.42%，对照组分别为22.92%、29.17%，两组比较差异均有统计学意义（P＜0.05）。同时研究组相关AST、ALT和TBIL等肝功能指标均低于对照组，两组比较差异均有统计学意义（P＜0.05）。结论：对抗结核药所致药物性肝炎患者，予多烯磷脂酰胆碱联合治疗效果显著，症状和肝功能相关指标明显改善，具有一定的临床应用和研究价值。

The Clinical Efficacy of Polyene Phosphatidylcholine on Hepatitis Induced by Anti-TB Drugs

Objective：To investigate the efficacy of polyene phosphatidylcholine in treating the anti-TB drug-induced hepatitis. Method：A total of 96 patients who were treated for drug-induced hepatitis at the hospital from October 2011 to October 2013 were enrolled in this study. Those patients were randomly split into two groups with 48 cases for each group. The control group was treated with inosine,potassium-magnesium aspartate and Glucurolactone,while the experimental group was treated with Polyene phosphatidylcholine. The difference of clinical efficacy,symptom improvement and liver functionality for both groups were analyzed. Result：The effective rate of the control group was 79.17%while the experimental group was 93.75% after treatment,and the difference between the two groups was statistically significant（P〈0.05）. In addition,the percentages of dark urine and yellowing of skin sclera were 6.25%and 10.42%for the experimental group respectively,better than the 22.92% and 29.17% for the control group,and the difference between the two groups were all statistically significant （P〈0.05）. The liver function indicators such as AST,ALT and TBIL were all lower for the experimental group than for the control group,and the difference was statistically significant（P〈0.05）. Conclusion：The polyene phosphatidylcholine combination therapy has significantly higher treatment efficacy on treating the anti-TB drug-induced hepatitis. This therapy can significantly improve the symptoms and the related liver function indicators and is valuable for clinical applications and research.