来曲唑和氯米芬治疗多囊卵巢综合征疗效分析

目的：比较来曲唑（LE）与枸橼酸氯米芬（cc）促排卵治疗多囊卵巢综合征（PCOS）的应用效果。方法：回顾本院2011年7月-2013年10月190例多囊卵巢综合征患者，分为LF组和CC组。比较两组的排卵率、临床妊娠率、早期流产率、多胎妊娠率和中重度卵巢过度刺激综合征（OHSS）的发生情况。结果：两组患者排卵率、自然流产率及多胎妊娠率比较差异均无统计学意义（P〉0．05）。但是LE组临床妊娠率明显高于CC组，OHSS发生率明显低于CC组，两组比较差异均有统计学意义（P〈0．05）。结论：LE促排卵更接近于人体的自然周期，与传统CC促排卵相比可有效提高临床妊娠率，降低卵巢过度刺激综合症发生率。在相同促排卵效果下LE在预防自然流产及多胎妊娠方面优于CC。

The Analysis of Therapeutic Effect of Letrozole and Clomifene Citrate in PCOS Patients

Objective： To compare letrozole with clomiphene citrate for ovulation induction treatment of polycystic ovary syndrome. Method： Review 190 polycystic ovary syndrome patients treated in Zhengzhou Central Hospital affiliated to Zhengzhou University from July 2011 to October 2013. The patients were divided into the LE group and the CC group. The ovulation rate, clinical pregnancy rate, delivery rate, early miscarriage rate, multiple pregnancy and OHSS rate were compared. Result： The ovulation rate, spontaneous abortion rate and multiple pregnancy rates between the two groups of patients were not statistically significant （ P〉0.05 ） . The LE group＇s clinical pregnancy rate was significantly higher than the CC group, the OHSS incidence was significantly lower than the CC group, and the diffe~nces between the two groups were all statistically significant （P〈0.05） . Conclusion： LE for ovulation is closer to the body＇s natural cycle, compared with the traditional CC for ovulation it can effectively improve the clinical pregnancy rate, reduce the incidence of ovarian hyperstimulation syndrome. With the same ovulation effect, LE is better than CC in the prevention of spontaneous abortion and multiple pregnancy.