氟哌噻吨美利曲辛联合奥美拉唑与莫沙比利治疗功能性消化不良的疗效观察

目的：探讨氟哌噻吨美利曲辛联合奥美拉唑与枸橼酸莫沙比利治疗功能性消化不良的疗效。方法：选择本院门诊治疗的190例功能性消化不良患者，随机分为观察组和对照组各95例，观察组给予氟哌噻吨美利曲辛片1片/d，晨服，睡眠不佳者中午加服1片，奥美拉唑20 mg，2次/d，枸橼酸莫沙比利5 mg，3次/d，治疗4周；对照组给予奥美拉唑20 mg，2次/d，枸橼酸莫沙比利5 mg，3次/d，治疗4周。观察两组患者治疗前及治疗4周后的临床症状改善情况，并对临床疗效及不良反应进行评价。结果：两组患者治疗4周后症状均明显减轻（P〈0.01），观察组治疗后的症状平均总评分、显效率和总有效率明显高于对照组，两组比较差异有统计学意义（P〈0.05）；两组不良反应发生率比较差异无统计学意义（P〉0.05）。结论：抗抑郁药联合PPI与促动力药治疗功能性消化不良优于PPI加用促动力药，可提高功能性消化不良的治疗效果。氟哌噻吨美利曲辛联合奥美拉唑与枸橼酸莫沙比利治疗功能性消化不良疗效高，不良反应发生率低。

Therapeutic Effect of Flupentixol and Melitracen Combined with Omeprazole and Mosapride Citrate in ;Treatment of Functional Dyspepsia

Objective：To investigate the therapeutic effect of flupentixol and melitracen combined with omeprazole and mosapride citrate in treatment of functional dyspepsia.Method：190 cases of patients with functional dyspepsia were randomly divided into observation group and control group,each of 95 cases.The observation group was given flupentixol and melitracen combined 1 tablet/d in morning,noon to add 1 tablet for poor sleep patient,omeprazole 20 mg,2 times/d,mosapride citrate combined 5 mg,3 times/d,treatment of 4 weeks.The control group was given omeprazole 20 mg,2 times/d,mosapride citrate combined 5 mg,3 times/d,treatment of 4 weeks. Dyspepsia symptoms were evaluated during visits before or 4 weeks after treatment. The clinical effects and the side effects of two groups were compared. Result：After 4 weeks treatment all symptoms had been improved,and symptoms scores were significantly decreased（P〈0.01）. The observation group’s average total score,the symptoms of significant efficiency and total effective rate significantly higher than those of control group,there were significant differences（P〈0.05）.There was no significant differences in the side effects between the two groups（P〉0.05）.Conclusion：Antidepressant drugs with PPI and promote gastric motility drugs will advance the treatment effect of functional dyspepsia than that of PPI combine with promote gastric motility drugs. Flupentixol and melitracen combined with omeprazole and mosapride citrate in treatment of functional dyspepsia is efficiently and the side effects rates is lower.