Reversal of HIV-1-associated osteoporosis with once-weekly alendronate |
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Authors: | Negredo Eugenia Martínez-López Eva Paredes Roger Rosales Joaquim Pérez-Alvarez Núria Holgado Susana Gel Silvia del Rio Luís Tena Xavier Rey-Joly Celestino Clotet Bonaventura |
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Affiliation: | Lluita contra la SIDA Foundation, Germans Trias i Pujol University Hospital, Badalona, Barcelona, Spain. |
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Abstract: | HIV-1-infected patients with osteoporosis were randomly assigned to alendronate 70 mg once-weekly plus dietary counselling (n = 11) or diet counselling alone (n = 14). At week 96, 27% of patients on alendronate versus 96% of controls presented with osteoporosis. Spine bone mineral density (BMD) increases were detected at week 48, and progressed thereafter. Improvements in trochanter BMD were obtained after 2 years. Once-weekly oral alendronate may be an effective and safe treatment for HIV-1-associated osteoporosis. |
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