| 益肤酰胺合成路线的研究 |
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| 引用本文： | 刘百里,刘宝林,王雪菡. 益肤酰胺合成路线的研究[J]. 沈阳药科大学学报, 1988, 0(1) |
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| 作者姓名： | 刘百里 刘宝林 王雪菡 |
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| 作者单位： | 沈阳药学院合成药物研究室，沈阳药学院，沈阳药学院制药厂 87届化学制药专业毕业生 |
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| 摘 要： | 我们曾以乙酰水杨酸为起始原料,经氯化、缩合、水解制得本品。由于该法合成路线较长,所用有机溶剂的种类较多,用量亦较大。因此,我们又研究了将水杨酸与对乙氧基苯胺直接缩合方法,用“均匀没计”法考察了它的主要影响因素,经多元回归分析,从建立的回归方程的各因素考察范围内优选出较佳工艺条件,收率达42.6%。
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| 关 键 词： | 益肤酰胺 水杨酸 对乙氧基苯胺 均匀设计 |
STUDY OF THE SYNTHETIC ROUTE OF EFUAMIDE |
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| Liu Baili,Liu Baolin,Wang Xuehan,Research. STUDY OF THE SYNTHETIC ROUTE OF EFUAMIDE[J]. Journal of Shenyang Pharmaceutical University, 1988, 0(1) |
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| Authors: | Liu Baili Liu Baolin Wang Xuehan Research |
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| Affiliation: | Liu Baili,Liu Baolin,Wang Xuehan,Research Department of Synthetic Drugs |
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| Abstract: | Efuamide was manufactured, using acetylsalicylic acid as starting material th-rough chloridization, condensation and hydrolysis. Because the synthetic route waslong and too many solvents wine needed in amounts, we tried direct condensationof salicylic acide and p-phenetidine. After inspecting the main influencing factorsof the process with Uniform Design, we chose a better synthetic condition fromthe inspected range of the factors in the established regression equation by meansof pluralistic regression analysis, with a yield of 42.6%. |
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| Keywords: | Efuamide Salicylic acid p-Phenetidine Uniform design |
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